谷胱甘肽硫转移酶作为生物标记物在环境风险评估中的应用进展  

Application progress of glutathione S-transferase as a biomarker in environmental risk assessment

作　　者：王宽[1] 靳春鹏[1] 张晓梅[2] 张鸿伟[2] 梁成珠[2] 鲍蕾[2] 

机构地区：[1]国家知识产权局专利局专利审查协作北京中心,北京100190 [2]山东出入境检验检疫局技术中心,青岛266001

出　　处：《食品安全质量检测学报》2015年第6期2235-2240,共6页Journal of Food Safety and Quality

基　　金：山东检验检疫局科研计划项目(SK201214)~~

摘　　要：水体、土壤等环境污染近年来呈加剧趋势,严重影响食物质量安全,威胁人类健康,环境污染物及其毒性效应研究越来越受到重视。谷胱甘肽硫转移酶(glutathione S-transferase,GST)作为分子水平上的生物标记物,由于具有特异性和预警性等特点受到广泛关注,在水体和土壤等环境生态风险评估中具有巨大的应用潜力。本文综述了GST作为指示环境污染早期预警指标的生态毒理学机制以及其对环境污染物的响应研究现状,指出了目前应用中存在的问题,并展望了其在环境风险评价中的发展趋势。Water, soil and other environmental pollution trends were exacerbated in recent years, which affected food quality and safety and threatened human health seriously. Environmental pollutants and their toxic effects had been paid more and more attention. Glutathione S-transferase enzyme (GST) attracted concerns widespreadly as a biomarker in the molecular level due to its specific and warning characteristics, and it had a huge potential application in water and soil risk assessment. This paper reviewed the mechanism of GST as an early warning indicator of environmental pollutions and its response, pointed out the problems in the current application, and looked into the prospect of its environmental risk assessment trends.

关 键 词：谷胱甘肽硫转移酶 生物标记物 水体污染 土壤污染 风险评估 

分 类 号：X171.4[环境科学与工程—环境科学] X820.4