长期摄入不同钙化合物对大鼠铝、铅吸收及大脑、骨骼蓄积的影响(英文)  

Effects of long-term ingestion of different calcium compounds on the absorption of aluminum and lead and their accumulation in rat brain and bone

作　　者：王劲[1] 柳启沛[1] 黄宗枝[2] 

机构地区：[1]复旦大学公共卫生学院营养与食品卫生学教研室,上海200032 [2]中科院原子核研究所,上海201800

出　　处：《中国临床康复》2004年第6期1188-1189,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:探讨不同钙化合物对大鼠铝、铅代谢的影响。方法:将幼年Sprague-Dawley大鼠30只(雌雄性各半),分成柠檬酸钙+铝+铅组、醋酸钙+铝+铅组和碳酸钙+铝+铅组等3组。各组动物分别用不同形式的钙化合物通过灌胃给予等剂量钙元素,共4周。实验结束后,用电感耦合等离子体原子发射光谱法(ICP-AES)分别测定全血、肝、肾、股骨和大脑中铝和铅的含量。结果:醋酸钙组、柠檬酸钙组和碳酸钙组铅的表观吸收率分别为(-29.97±28.85)%,(-86.20±87.60)%和(-163.56±93.77)%;大脑中铝浓度分别为(3.84±1.49),(3.67±1.31)和(0.83±1.61)μg/g。大鼠摄入醋酸钙和柠檬酸钙后对铅的表观吸收率要高于碳酸钙组的大鼠(F=-23.744,7.802,P<0.05)。摄入柠檬酸钙和醋酸钙的大鼠的大脑和骨骼组织中铝和铅水平高于摄入碳酸钙的大鼠(F=12.411～38.333,P<0.05)。结论:长期摄入柠檬酸钙和醋酸钙有增加铅吸收的危险,并可使铅和铝蓄积在骨骼和大脑。AIM: To explore the effects of different calcium compounds on aluminum(Al) and lead(Pb) metabolism in rats. METHODS: Thirty young rats(15 male and 15 female),were divided into three groups: Ca citrate+ Al+ Pb group,Ca acetate+ Al+ Pb group,and Ca carbonate+ Al+ Pb group.The rats of each group were given calcium element of the same dosage by gavage of various calcium compounds for four weeks.After the experiment,Al and Pb levels in whole blood,liver,kidney, femur and cerebrum were measured by ICP AES. RESULTS:In the Ca acetate+ Al+ Pb group,Ca citrate+ Al+ Pb group and Ca carbonate+ Al+ Pb group,the apparent absorptivity of Pb(- 29.97± 28.85)% ,(- 86.20± 87.60)% and(- 163.56± 93.77)% ; concentration of Al in cerebrum: (3.84± 1.49),(3.67± 1.31) and (0.83± 1.61)μ g/g.The absorptivities of Pb in the rats treated with calcium citrate and calcium acetate were higher than those treated with calcium carbonate.The aluminum and lead levels in the cerebrum and bone in the rats treated with calcium citrate and calcium acetate were higher than those treated with calcium carbonate. CONCLUSION:Long term ingestion of Ca acetate and Ca citrate presents a risk of enhancing Al and Pb absorption and making them retained in the cerebrum and bone.

关 键 词：钙化合物 大鼠 铝吸收 铅吸收 大脑蓄积 骨骼蓄积 柠檬酸钙 醋酸钙 碳酸钙 铝代谢 铅代谢 

分 类 号：R977.5[医药卫生—药品] R-33[医药卫生—药学]