白藜芦醇及其类似物的合成及抗TPA促癌作用研究  

Studies on the synthesis of resveratrol and its analogs and their antipromotion of TPA

作　　者：陈国良[1] 单韦[1] 徐颖[2] 董金华[1] 张宝凤[2] 计志忠[1] 

机构地区：[1]沈阳药科大学制药工程学院,辽宁沈阳110016 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《沈阳药科大学学报》2004年第4期261-263,共3页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金青年基金资助项目 (3980 0 185 )

摘　　要：目的设计合成白藜芦醇类似物 ,并测试其抗佛波酯 (TPA)促癌作用。方法以 3,5 二羟基苯甲酸为原料经多步反应合成目标化合物 ,采用TPA致小鼠耳肿胀促癌法确定目标化合物抗TPA促癌作用。结果所有合成的目标化合物通过1H NMR确认其结构 ,大部分化合物具有明显的抗TPA促癌作用。结论白藜芦醇及其类似物具有较强抗TPA促癌作用。Objective To design and synthesize resveratrol and its analogs,and to assay their activity of preventing the cancer induced by TPA.Methods The target compounds were synthesized from 3,5-dihydroxybenzoic acid.The activity of preventing the cancer induced by TPA was tested.Result The structures of all the target compounds synthesized were confirmed by 1H-NMR.Most target compounds had potent activity of preventing the cancer induced by TPA.Conclusions Resveratrol and its analogs show good antipromotion activity of TPA.

关 键 词：制备 化学合成 白藜芦醇类似物 抗促癌 TPA 

分 类 号：R914[医药卫生—药物化学]