海岛居民膳食营养与胃癌关系的病例对照研究  

A case--control study on the relationship between nutrition and gastric cancer in islanders

作　　者：裘炯良[1] 陈坤[2] 王旭波[3] 王建跃[4] 张立军[4] 水黎明[2] 

机构地区：[1]宁波出入境检验检疫局卫生检疫处,315012 [2]浙江大学医学院流行病学教研室 [3]丽水师范专科学校医学部 [4]舟山市疾病预防控制中心

出　　处：《中华流行病学杂志》2004年第6期487-491,共5页Chinese Journal of Epidemiology

基　　金：卫生部基金(WKZ-2001-1-17)

摘　　要：目的 研究海岛地区居民膳食营养素摄入量与胃癌发病的关系。方法 采用频数匹配的病例对照研究方法,随机选择舟山市原发性胃癌新发病例103例和健康人群对照133名,进行有关饮食因素的调查,并把各饮食项目折算成16种营养素的日均摄入量后以非条件logistic回归法分析其与胃癌发生的关系。结果 在调整了非饮食因素和总热能对各项营养素的干扰后,蛋白质(OR_(Q4vs.Q1) =10.3;趋势检验的P=0.01)、饱和脂肪酸(OR_(Q4vs.Q1)=3.24)、胆固醇(OR_(Q4vs.Q1=2.76)等在男性组为胃癌的危险因素,无论男、女性组钠的摄入量均为病例组高于对照组;而维生素A、C在女性组均为胃癌的保护因素。结论 高蛋白质、饱和脂肪酸、胆固醇、盐及低维生素A、C饮食可能是胃癌的危险因素。Objective To study the association between nutritional factors and gastric cancer in islanders. Methods A population-based case-control study on diet and gastric cancer was carried out in Zhoushan islands,China. 103 cases of gastric cancer newly diagnosed in 2001 and 133 controls frequency- matched by age, sex, and islands of residence among residents in Zhouhan were included in the study. Dietary intake was estimated using a constructed food freqency questionnaire. Total calories and 15 nutrients were calculated according to the food composition table and their adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated by gender using unconditional logistic regression models. Results Increased risks of gastric cancer were associated with protein (OR_(Q4USQ1)=10.3; P for linear trend=0.01), saturated fat (OR_(Q4USQ1= 3.24), and cholesterol(OR_(Q4USQ1)=2.76) particularly among males. Among females, carbohydrate was a significant high-risk nutrient (OR^(Q4USQ1)=14.8; P for linear trend=0.024). In both sexes, all cases reported a significantly higher daily intake of natrium mainly from salts than controls. An inversed association with the risk of gastric cancer was seen in vitamin A and vitamin C. Conclusion The findings from this study provided information about the role of specific nutrients in the etiology of gastric cancer. High intakes of protein, saturated fat, cholesterol, sodium and poor intakes of vitamin A and C could increase the risk of gastric cancer.

关 键 词：海岛居民 膳食 营养 胃癌 危险因素 

分 类 号：R735.2[医药卫生—肿瘤]