Fertility Preservation in Premature Ovarian Insufficiency (POI) Secondary to FSH Receptor Gene (FSHR) Mutation: Is There a New Hope?  

作　　者：Pierre-Antoine Pradervand Roland Antaki Simon Phillips C. Sylvestre Zaki El Haffaf Ariane Godbout Isaac Jacques Kadoch Pierre Lehmann 

机构地区：[1]OVO Fertility, OVO Clinic, Montreal, Canada [2]Assisted Procreation Clinic, Centre Hospitalier de l’Université de Montréal (CHUM), Montreal, Canada [3]Division of Reproductive Endocrinology and Infertility, Centre Hospitalier Universitaire (CHU) Ste-Justine, Montreal, Canada [4]Department of Obstetrics and Gynecology, Hôpital Sacré Coeur de Montréal, Montreal, Canada

出　　处：《Case Reports in Clinical Medicine》2017年第10期274-280,共7页临床医学病理报告（英文）

摘　　要：A 19 years old patient with primary amenorrhea was referred to our center. Based on discrepancy between high follicle stimulating hormone (FSH) level and normal ovarian reserve parameters, follicle stimulating hormone receptor (FSHR) mutation was screened. The patient was homozygous in exon 6 of the FSHR gene for the new variant c.479T > C and predicted to result in an aminoacid substitution p.Ile160Thr. One year later, her anti-müllerian hormone (AMH) level inexplicably decreased. Oocyte vitrification was thus offered for fertility preservation. After 17 days of recombinant follicle stimulating hormone (recFSH) (900 IU daily), no follicular growth was seen and estradiol levels remained low. In vitro maturation (IVM) was then suggested. Ten oocytes were successfully vitrified.A 19 years old patient with primary amenorrhea was referred to our center. Based on discrepancy between high follicle stimulating hormone (FSH) level and normal ovarian reserve parameters, follicle stimulating hormone receptor (FSHR) mutation was screened. The patient was homozygous in exon 6 of the FSHR gene for the new variant c.479T > C and predicted to result in an aminoacid substitution p.Ile160Thr. One year later, her anti-müllerian hormone (AMH) level inexplicably decreased. Oocyte vitrification was thus offered for fertility preservation. After 17 days of recombinant follicle stimulating hormone (recFSH) (900 IU daily), no follicular growth was seen and estradiol levels remained low. In vitro maturation (IVM) was then suggested. Ten oocytes were successfully vitrified.

关 键 词：FSH Receptor MUTATION Fertility Preservation in VITRO Maturation AMH Primary OVARIAN INSUFFICIENCY 

分 类 号：R73[医药卫生—肿瘤]