Artificial Sweeteners as a Cause of Obesity: Weight Gain Mechanisms and Current Evidence  

作　　者：Thiago Magalhã es Cabral Maira Guimarã es Barboza Pereira Amanda Emiko Zensque Falchione Diana Aristotelis Rocha de Sá Luciana Correa Daniela da Maia Fernandes Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex 

机构地区：[1]Endocrinology Division, IPEMED Medical School, Sã o Paulo, Brazil [2]Diabetology Department, Malteser Krankenhaus St.-Franziskus Hospital, Flensburg, Germany [3]Harvard T. H. Chan School of Public Health, Boston, MA, USA

出　　处：《Health》2018年第5期700-717,共18页健康（英文）

摘　　要：The obesity epidemic gathers growing media attention recently, as overweight and obesity’s prevalence keeps rising. This comes along with an increase in the intake of artificial sweeteners in food products. A causal relationship between the consumption of sweeteners and obesity is so far not clear in the medical literature. This paper describes the development of artificial sweeteners in a historical context. It collects epidemiological and experimental evidence that possibly relates the use of artificial sweeteners with weight gain. Finally, these effects are explained based on the neuroscience of food reward, the possible effects of glucose on the metabolism and the association between sweeteners and gut microbiota.The obesity epidemic gathers growing media attention recently, as overweight and obesity’s prevalence keeps rising. This comes along with an increase in the intake of artificial sweeteners in food products. A causal relationship between the consumption of sweeteners and obesity is so far not clear in the medical literature. This paper describes the development of artificial sweeteners in a historical context. It collects epidemiological and experimental evidence that possibly relates the use of artificial sweeteners with weight gain. Finally, these effects are explained based on the neuroscience of food reward, the possible effects of glucose on the metabolism and the association between sweeteners and gut microbiota.

关 键 词：SWEETENERS Weight GAIN OBESITY MICROBIOTA CYCLAMATE SUCRALOSE 

分 类 号：R5[医药卫生—内科学]