Impact of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection  

作　　者：Kalpana J. Kallianpur Rasmus Birn Lishomwa C. Ndhlovu Scott A. Souza Brooks Mitchell Robert Paul Dominic C. Chow Lindsay Kohorn Cecilia M. Shikuma Kalpana J. Kallianpur;Rasmus Birn;Lishomwa C. Ndhlovu;Scott A. Souza;Brooks Mitchell;Robert Paul;Dominic C. Chow;Lindsay Kohorn;Cecilia M. Shikuma(Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii-Manoa, Honolulu, HI, USA;Center for Translational Research on Aging, Kuakini Medical Center, Honolulu, HI, USA;Hawaii Center for AIDS, University of Hawaii-Manoa, Honolulu, HI, USA;Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA;Weill Cornell Medicine, New York, NY, USA;The Queen’s Medical Center, Honolulu, HI, USA;Missouri Institute of Mental Health, University of Missouri-St Louis, St. Louis, MO, USA)

机构地区：[1]Department of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii-Manoa, Honolulu, HI, USA [2]Center for Translational Research on Aging, Kuakini Medical Center, Honolulu, HI, USA [3]Hawaii Center for AIDS, University of Hawaii-Manoa, Honolulu, HI, USA [4]Department of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA [5]Weill Cornell Medicine, New York, NY, USA [6]The Queen’s Medical Center, Honolulu, HI, USA [7]Missouri Institute of Mental Health, University of Missouri-St Louis, St. Louis, MO, USA

出　　处：《Journal of Behavioral and Brain Science》2020年第8期344-370,共27页行为与脑科学期刊（英文）

摘　　要：<strong>Background</strong>: Brain atrophy and cognitive deficits persist among individuals with suppressed HIV disease. The impact of cannabis use is unknown. <strong>Methods</strong>: HIV+ and HIV- participants underwent cross-sectional magnetic resonance imaging and neuropsychological testing. Lifetime frequency, duration (years), and recency of cannabis use were self-reported. Relationships of cannabis use to resting-state functional connectivity (RSFC) and to 9 regional brain volumes were assessed with corrections for multiple comparisons. Peripheral blood cytokines and monocyte subsets were measured in the HIV+ group and examined in relation to cannabis exposure. <strong>Results</strong>: We evaluated 52 HIV+ [50.8 ± 7.1 years old;100% on antiretroviral therapy ≥ 3 months;83% with plasma viral load < 50 copies/mL] and 55 HIV- [54.0 ± 7.5 years old] individuals. Among HIV+ participants, recent cannabis use (within 12 months) was associated with diminished RSFC, including of occipital cortex, controlling for age. Duration of use correlated negatively with volumes of all regions (most strikingly the nucleus accumbens) independently of recent use and intracranial volume. Recent use was associated with larger caudate and white matter volumes and lower soluble vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 concentrations. Duration of use correlated positively with psychomotor speed. Use > 10 times/lifetime was linked to more somatic symptoms, better executive function, and lower CD14⁺CD16^{<span style="white-space:normal;"></span>++}<span style="white-space:normal;"></span> monocyte count. <strong>Conclusion</strong>: HIV+ individuals demonstrated opposing associations with cannabis. Recent use may weaken RSFC and prolonged consumption may exacerbate atrophy of the accumbens and other brain regions. More frequent or recent cannabis use may reduce the inflammation and CD14^{<span style="white-space:normal;"></span>+}<span style="white-s<strong>Background</strong>: Brain atrophy and cognitive deficits persist among individuals with suppressed HIV disease. The impact of cannabis use is unknown. <strong>Methods</strong>: HIV+ and HIV- participants underwent cross-sectional magnetic resonance imaging and neuropsychological testing. Lifetime frequency, duration (years), and recency of cannabis use were self-reported. Relationships of cannabis use to resting-state functional connectivity (RSFC) and to 9 regional brain volumes were assessed with corrections for multiple comparisons. Peripheral blood cytokines and monocyte subsets were measured in the HIV+ group and examined in relation to cannabis exposure. <strong>Results</strong>: We evaluated 52 HIV+ [50.8 ± 7.1 years old;100% on antiretroviral therapy ≥ 3 months;83% with plasma viral load < 50 copies/mL] and 55 HIV- [54.0 ± 7.5 years old] individuals. Among HIV+ participants, recent cannabis use (within 12 months) was associated with diminished RSFC, including of occipital cortex, controlling for age. Duration of use correlated negatively with volumes of all regions (most strikingly the nucleus accumbens) independently of recent use and intracranial volume. Recent use was associated with larger caudate and white matter volumes and lower soluble vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1 concentrations. Duration of use correlated positively with psychomotor speed. Use > 10 times/lifetime was linked to more somatic symptoms, better executive function, and lower CD14⁺CD16^{<span style="white-space:normal;"></span>++}<span style="white-space:normal;"></span> monocyte count. <strong>Conclusion</strong>: HIV+ individuals demonstrated opposing associations with cannabis. Recent use may weaken RSFC and prolonged consumption may exacerbate atrophy of the accumbens and other brain regions. More frequent or recent cannabis use may reduce the inflammation and CD14^{<span style="white-space:normal;"></span>+}<span style="white-s

关 键 词：Resting-State Functional Connectivity OCCIPITAL ATROPHY INFLAMMATION MONOCYTES 

分 类 号：R51[医药卫生—内科学]