The Mechanism and Research Progress of Ferroptosis in Esophageal Squamous Cell Carcinoma  

作　　者：Jinmeng Gong Xiaoping Tan Jinmeng Gong;Xiaoping Tan(Department of Gastroenterology, The First Affiliated Hospital of Yangtze University, Jingzhou, China;Medical College of Yangtze University, Jingzhou, China;Digestive Disease Research Institution of Yangtze University, Jingzhou, China)

机构地区：[1]Department of Gastroenterology, The First Affiliated Hospital of Yangtze University, Jingzhou, China [2]Medical College of Yangtze University, Jingzhou, China [3]Digestive Disease Research Institution of Yangtze University, Jingzhou, China

出　　处：《Journal of Biosciences and Medicines》2023年第10期241-254,共14页生物科学与医学（英文）

摘　　要：Esophageal squamous cell carcinoma (ESCC), as the main histological type of esophageal cancer (EC), has the characteristics of high malignant degree, high mortality and tendency to lymph node metastasis. Despite the combination of surgery and chemoradiotherapy, ECSS has a poor prognosis. Ferroptosis is a newly discovered iron-dependent programmed cell death pattern characterized by the accumulation of lipid peroxidation and characteristic morphological changes of mitochondria. It regulates the growth and invasion of cancer cells in various tumors such as gastric cancer and pancreatic cancer. In this article, we mainly introduce the ferroptosis regulatory mechanism in ESCC, hoping to provide a new direction and ideas for the treatment of ECSS.Esophageal squamous cell carcinoma (ESCC), as the main histological type of esophageal cancer (EC), has the characteristics of high malignant degree, high mortality and tendency to lymph node metastasis. Despite the combination of surgery and chemoradiotherapy, ECSS has a poor prognosis. Ferroptosis is a newly discovered iron-dependent programmed cell death pattern characterized by the accumulation of lipid peroxidation and characteristic morphological changes of mitochondria. It regulates the growth and invasion of cancer cells in various tumors such as gastric cancer and pancreatic cancer. In this article, we mainly introduce the ferroptosis regulatory mechanism in ESCC, hoping to provide a new direction and ideas for the treatment of ECSS.

关 键 词：ESCC Ferroptosis System Xc? GPX4 PUFA MUFA Fe²⁺ ROS Lipid Peroxidation 

分 类 号：R73[医药卫生—肿瘤]