Aminated Cyclopropylmethylphosphonates as Potent Prostate Cancer Inhibitors  

作　　者：Abed Al Aziz Al Quntar Ibrahim Abasy Abed Al Aziz Al Quntar;Ibrahim Abasy(Department of Chemistry and Chemical Technology, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine;Department of Microbiology and Immunology, Al-Quds University, Jerusalem, Palestine)

机构地区：[1]Department of Chemistry and Chemical Technology, Faculty of Science and Technology, Al-Quds University, Jerusalem, Palestine [2]Department of Microbiology and Immunology, Al-Quds University, Jerusalem, Palestine

出　　处：《Journal of Biosciences and Medicines》2024年第7期239-244,共6页生物科学与医学（英文）

摘　　要：Inspired by the anti-pancreatic promising results of our novel aminated cyclopropylmethylphosphonate compounds, an in vitro anti-prostate cancer activity exploration of these compounds was carried out on human prostate cancer cell line PC-3, and showed potent inhibiting activity at low micromolar concentrations (with an IC50 of approximately 45 μM).Inspired by the anti-pancreatic promising results of our novel aminated cyclopropylmethylphosphonate compounds, an in vitro anti-prostate cancer activity exploration of these compounds was carried out on human prostate cancer cell line PC-3, and showed potent inhibiting activity at low micromolar concentrations (with an IC50 of approximately 45 μM).

关 键 词：Prostate Cancer Cancer Cyclopropylphophonates AMINOPHOSPHONATES CYCLOPROPANES PHOSPHONATES Alkynylphosphonates ANTI-CANCER Prostate 

分 类 号：R73[医药卫生—肿瘤]