The Role of NF-κβ and HIF-1α in the Formation of Deep Vein Thrombosis  

作　　者：Erchang Zhu Yueqiu Liu Lei Li Erchang Zhu;Yueqiu Liu;Lei Li(Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China)

机构地区：[1]Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China

出　　处：《Journal of Biosciences and Medicines》2024年第9期307-313,共7页生物科学与医学（英文）

摘　　要：Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1α in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1α in patients with DVT compared to a healthy control group, utilizing ELISA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1α in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1α in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1α in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1α in patients with DVT compared to a healthy control group, utilizing ELISA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1α in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1α in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.

关 键 词：DVT NF-ΚΒ HIF-1Α INFLAMMATION BIOMARKER 

分 类 号：R73[医药卫生—肿瘤]