Role of lncRNAs in GI Cancer  

作　　者：Murali Krishna Anju Mullath 

机构地区：[1]Military Hospital, Palampur, India [2]DNB Gastroenterology Lakeshore Hospital and Research Centre, Cochin, India

出　　处：《Journal of Cancer Therapy》2018年第3期281-298,共18页癌症治疗（英文）

摘　　要：lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.lncRNAs forms a part of the non coding part of human genome. This term denotes specific non coding RNAs with nucleotide length more than 200. They have been shown to affect various physiological and pathological processes within the human body. Of interest is their role in malignant transformation in several cancers. In this review, the role of lncRNAs in GI cancers namely pancreatic cancer, gastric cancer, hepatocellular cancer and colorectal cancer have been explained in brief. These lncRNAs have shown to be useful as a marker for detection and prognosis of various malignancies. They also have shown to have therapeutic potential. Various relevant lncRNAs in each section has also been mentioned.

关 键 词：lncRNA CANCER PANCREATIC GASTRIC HEPATOCELLULAR COLORECTAL 

分 类 号：R73[医药卫生—肿瘤]