Effect of Aqueous Extract of <i>Phoenix dactylifera</i>Pollen on Dopamine System of Nucleus Accumbens in Male Rats  

作　　者：Ali Abedi Seyyed Morteza Karimian Mohsen Parviz Perham Mohammadi Hamid Reza Sadeghipour Roudsari 

机构地区：[1]Pharmacology Department, School of Pharmacy, Ar-dabil University of Medical Sciences, Ardabil, Iran [2]Physiology Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran [3]Physiology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

出　　处：《Neuroscience & Medicine》2014年第1期49-59,共11页神经系统科学与医药（英文）

摘　　要：Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmission in the nucleus accumbens was studied in male rats using in vivo microdialysis. Results: Releasing of dopamine increased significantly in the nucleus accumbens when a receptive female was introduced behind a screen (p 0.001). During copulation, dopamine increased markedly in control and treated rats. Phoenix dactylifera Date Palm Pollen enhanced the orientation of males towards females by increasing mounting and ano-genital investigatory behavior. Improving of sexual behavior and dopamine release was higher in treated rats in comparison with control (p 0.001). Conclusion: These results indicate a neurochemical basis for interaction between dopaminergic agents and male sexual behavior. Therefore, Phoenix dactylifera Date Palm Pollen seems to act as a dopamine agonist and to cure male infertility. It can be used as an aphrodisiac that leads to further increases in dopamine release.Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmission in the nucleus accumbens was studied in male rats using in vivo microdialysis. Results: Releasing of dopamine increased significantly in the nucleus accumbens when a receptive female was introduced behind a screen (p 0.001). During copulation, dopamine increased markedly in control and treated rats. Phoenix dactylifera Date Palm Pollen enhanced the orientation of males towards females by increasing mounting and ano-genital investigatory behavior. Improving of sexual behavior and dopamine release was higher in treated rats in comparison with control (p 0.001). Conclusion: These results indicate a neurochemical basis for interaction between dopaminergic agents and male sexual behavior. Therefore, Phoenix dactylifera Date Palm Pollen seems to act as a dopamine agonist and to cure male infertility. It can be used as an aphrodisiac that leads to further increases in dopamine release.

关 键 词：PHOENIX dactylifera Date Palm POLLEN Dopamine Nucleus ACCUMBENS MICRODIALYSIS Male Rat 

分 类 号：R73[医药卫生—肿瘤]