The nucleus accumbens(NAc)is a subcortical brain structure known primarily for its roles in pleasure,reward,and addiction.Despite less focus on the NAc in pain research,it also plays a large role in the mediation of p...
grants from the National Key Basic Research Program of China(973 program,No.2015CB856401);the National Natural Science Foundation of China(Nos.81630031,81571321,and 81571312);the Peking University Medicine Seed Fund for Interdisciplinary Research(No.BMU2017MX021);the Beijing Brain Project(No.Z171100000117016).
Background:Exposure to adverse experiences in early life may profoundly reshape the neurodevelopmental trajectories of the brain and lead to long-lasting behavioral and neural alterations.One deleterious effect of ear...
National Basic Research Program of China(2015CB553504);National Natural Science Foundationof China (81471350;81671321);Natural Science Foundation of Ningbo Municipality,Zhejiang Province, China (2017A610214).
OBJECTIVE Glutamatergic projections from prefrontal cortex(PFc) to nucleus accumbens(NAc) regulate the dopamine(DA) release in NAc.However,it is not clear whether this circuit is effective for the reward and motivatio...
National Key Research and Development (2016YFC0800907);Project 973 (2015CB553504);National Natural Science Foundation of China(81573405);Beijing Nova Program(xx2014A014).
OBJECTIVE Dopamine(DA)plays important roles in Pavlovian conditioning by mediating reward,learning and motivation.While the conditioning stimulation(CS) is the most important inducement for reinstatement in addiction....
Mavridis' atrophy(MA) is called the human nucleus accumbens(NA) atrophy in Parkinson's disease(PD).MA begins in early-stage PD patients and is correlated with psychiatric symptoms that occur in PD, mainly apathy and i...
Cats placed in the situation of a choosing between a high-value time-delayed and a low-value immediate food rewards elected to wait for the preferred reward or to obtain the worse reward quickly. On the basis of the s...
Background: Dopamine has been known to facilitate male sexual function. Methods: The effect of aqueous extract (140 mg/kg) of Phoenix dactylifera date palm pollen on sexual behavior and determining of dopamine transmi...
The aim of this work was to investigate whether acamprosate modifies the expression of the enzyme responsible for neuronal NO synthesis (nNOS) in the nucleus accumbens (NAc) of mice chronically treated with morphine a...
The estrous cycle is a physiological process modulated by hormonal changes associated, in turn, with alterations of the attraction or sensitivity with which females perceive different sensory stimuli. Auditory stimuli...
The human nucleus accumbens(NA), a major part of the ventral striatum, is the area of continuity between the putamen and head of the caudate nucleus. It consists of two parts, a shell laterally and a core medially. Th...