Structural Changes in Vertebrae of Mice Based on Experimental Model of Rheumatoid Arthritis  

作　　者：Demid Oyuntsetseg Оchirpurev Мunkhjargal Chimed Mandalshaihan Avirmed Amgalanbaatar Enebish Sundui Hany Wahila Amgalanbaatar Dorjkhuu 

机构地区：[1]Department of Professional Science, Gobi-Altai School of Mongolian National University of Medical Sciences, Gobi-Altai, Mongolia [2]Morphology Department, Bio-Medicine and Pharmacology School of Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

出　　处：《Open Journal of Applied Sciences》2018年第1期1-11,共11页应用科学（英文）

摘　　要：Studies have shown that autoimmunity causes pathogenesis of more than 100 diseases. Among these diseases, approximately 1-2% of the world’s population has rheumatoid arthritis disease, which is a chronic disease that affects 45 out of every 3000 people who have autoimmune diseases. The aim of this research is to address the possible treatment of rheumatoid arthritis disease by comparing and contrasting the effectiveness and influence that treatments have on treating the disease. This study will be conducted by inducing the following treatments: ibuprofen and Boigor-10 on model animal subjects (mice) to determine the outcomes of the treatment. We will assess the outcomes by investigate the structural changes on vertebrae and joints of these subjects and the clinical manifestation score of each treatment. We hypothesize that these treatments will improve the treatment of rheumatoid arthritis disease. Furthermore, we hope that this research contributes to further understanding autoimmune disease and promotes proper treatment of the disease.Studies have shown that autoimmunity causes pathogenesis of more than 100 diseases. Among these diseases, approximately 1-2% of the world’s population has rheumatoid arthritis disease, which is a chronic disease that affects 45 out of every 3000 people who have autoimmune diseases. The aim of this research is to address the possible treatment of rheumatoid arthritis disease by comparing and contrasting the effectiveness and influence that treatments have on treating the disease. This study will be conducted by inducing the following treatments: ibuprofen and Boigor-10 on model animal subjects (mice) to determine the outcomes of the treatment. We will assess the outcomes by investigate the structural changes on vertebrae and joints of these subjects and the clinical manifestation score of each treatment. We hypothesize that these treatments will improve the treatment of rheumatoid arthritis disease. Furthermore, we hope that this research contributes to further understanding autoimmune disease and promotes proper treatment of the disease.

关 键 词：ARTHRITIS Joint Experiment PANNUS VERTEBRA HISTOLOGY 

分 类 号：R73[医药卫生—肿瘤]