Parametric and Non-Parametric Analysis of the Survival Times of Patients with Multiple Myeloma Cancer  

作　　者：Lohuwa Mamudu Chris P. Tsokos 

机构地区：[1]Department of Mathematics and Statistics, University of South Florida, Tampa, FL, USA

出　　处：《Open Journal of Applied Sciences》2020年第4期118-134,共17页应用科学（英文）

摘　　要：Multiple myeloma (MM) is a type of cancer that remains incurable. In the last decade, most research into MM has focused on investigating the improvement in the therapeutic strategy. Our study assesses the survival probability of 48 patients diagnosed with MM based on parametric and non-parametric techniques. We performed parametric survival analysis and found a well-def- ined probability distribution of the survival time to follow three-parameter lognormal. We then estimated the survival probability and compared it with the commonly used non-parametric Kaplan-Meier survival analysis of the survival times. The comparison of the survival probability estimates of the two methods revealed a better survival probability estimate by the parametric method than the Kaplan-Meier. The parametric survival analysis is more robust and efficient because it is based on a well-defined parametric probabilistic distribution, hence preferred over the non-parametric Kaplan-Meier. This study offers therapeutic significance for further enhancement in the treatment strategy of multiple myeloma cancer.Multiple myeloma (MM) is a type of cancer that remains incurable. In the last decade, most research into MM has focused on investigating the improvement in the therapeutic strategy. Our study assesses the survival probability of 48 patients diagnosed with MM based on parametric and non-parametric techniques. We performed parametric survival analysis and found a well-def- ined probability distribution of the survival time to follow three-parameter lognormal. We then estimated the survival probability and compared it with the commonly used non-parametric Kaplan-Meier survival analysis of the survival times. The comparison of the survival probability estimates of the two methods revealed a better survival probability estimate by the parametric method than the Kaplan-Meier. The parametric survival analysis is more robust and efficient because it is based on a well-defined parametric probabilistic distribution, hence preferred over the non-parametric Kaplan-Meier. This study offers therapeutic significance for further enhancement in the treatment strategy of multiple myeloma cancer.

关 键 词：Multiple MYELOMA CANCER Three-Parameter LOGNORMAL Kaplan-Meier Maximum LIKELIHOOD Estimation Health Science 

分 类 号：R73[医药卫生—肿瘤]