Intra-articular injection of xanthan gum: A potential therapy for osteoarthritis  

作　　者：Huarong Shao Guanying Han Peixue Ling Xiqiang Zhu Fei Liu Yan Jin Lijuan Zhao Tianmin Zhang 

机构地区：[1]Post-doctoral Scientific Research Workstation, Institute of Biopharmaceuticals of Shandong Province, Jinan, China [2]School of Pharmaceutical Sciences, Shandong University, Jinan, China

出　　处：《Advances in Bioscience and Biotechnology》2012年第4期449-453,共5页生命科学与技术进展（英文）

摘　　要：Osteoarthritis (OA) means inflammation of the joints, with the symptoms of joint pain, stiffness, and swelling of the joints. It is a degenerative disease that appears to be caused by both biomechanical and bio-chemical factors. Intra-articular (IA) injection treatment is one of the main treatment methods for OA because of its positive effect in reducing joint pain and increasing joint mobility. IA injection of xanthan gum (XG) could protect the joint cartilage, relieve the synovitis and reduce the OA progression in experiment OA. The injection of XG may have a long-lasting effect in the joint cavity, which could avoid frequent IA injections. However, for the development of this potential therapy, further studies such as the effective long-term pain relief properties, the detailed action mechanism and the pharmacokinetics of the XG injection will be conducted. This article briefly reviewed the preparation, safety evaluation, pharmacodynamics and possible action mechanism of XG injection, and come up with the ideas for further development of this potential therapy for OA.Osteoarthritis (OA) means inflammation of the joints, with the symptoms of joint pain, stiffness, and swelling of the joints. It is a degenerative disease that appears to be caused by both biomechanical and bio-chemical factors. Intra-articular (IA) injection treatment is one of the main treatment methods for OA because of its positive effect in reducing joint pain and increasing joint mobility. IA injection of xanthan gum (XG) could protect the joint cartilage, relieve the synovitis and reduce the OA progression in experiment OA. The injection of XG may have a long-lasting effect in the joint cavity, which could avoid frequent IA injections. However, for the development of this potential therapy, further studies such as the effective long-term pain relief properties, the detailed action mechanism and the pharmacokinetics of the XG injection will be conducted. This article briefly reviewed the preparation, safety evaluation, pharmacodynamics and possible action mechanism of XG injection, and come up with the ideas for further development of this potential therapy for OA.

关 键 词：OSTEOARTHRITIS XANTHAN Gum PHARMACODYNAMICS Action Mechnism 

分 类 号：R73[医药卫生—肿瘤]