Comparison of Plasma Levels of Tryptophan Metabolites between Healthy People and Patients of Bipolar Depression at Various Age and Gender  

作　　者：Hiroi Tomioka Junichi Masuda Akikazu Takada Akira Iwanami Hiroi Tomioka;Junichi Masuda;Akikazu Takada;Akira Iwanami(Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan;Department of Psychiatry, Showa University Northern Yokohama Hospital, Yokohama, Japan;Global Application Development Center, Shimadzu Corporation, Kanagawa-ken, Japan;International Projects on Food and Health (NPO), Tokyo, Japan)

机构地区：[1]Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan [2]Department of Psychiatry, Showa University Northern Yokohama Hospital, Yokohama, Japan [3]Global Application Development Center, Shimadzu Corporation, Kanagawa-ken, Japan [4]International Projects on Food and Health (NPO), Tokyo, Japan

出　　处：《Journal of Biomedical Science and Engineering》2020年第6期120-129,共10页生物医学工程（英文）

摘　　要：Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: Plasma levels of TRP are not different between HC and patients of BDII. Serotonin (5-HT) levels are higher in BDII than HC. Plasma levels of 5-HIAA of HC are higher than those of old women of BDII, but lower in young women of BDII. Plasma levels of kynurenine (KYN) of HC are not different from those of patients of BDII. Conclusion: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation and lower transporter biding may increase plasma levels of 5-HT in patients of BD.Background: It is not well analyzed whether there are differences in plasma levels of tryptophan (TRP) metabolites between healthy control people (HC) and patients of type II bipolar depression (BDII). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been used for the simultaneous determination of plasma levels of tryptophan metabolites in depressive patients. Results: Plasma levels of TRP are not different between HC and patients of BDII. Serotonin (5-HT) levels are higher in BDII than HC. Plasma levels of 5-HIAA of HC are higher than those of old women of BDII, but lower in young women of BDII. Plasma levels of kynurenine (KYN) of HC are not different from those of patients of BDII. Conclusion: Plasma levels of 5-HT are higher in patients of BDII than those of HC, which may suggest that use of drugs inhibiting the 5-HT transportation and lower transporter biding may increase plasma levels of 5-HT in patients of BD.

关 键 词：DEPRESSION Monopolar Depression Bipolar Depression TRYPTOPHAN SEROTONIN 5-Hydroxyindole Acetic Acid KYNURENINE SSRI (Selective Serotonin Reuptake Inhibitor) SNRI (Serotonin Norepinephrine Reuptake Inhibitor) ANXIOLYTIC Antipsychotic 

分 类 号：R73[医药卫生—肿瘤]