Endodermal progenitor cells isolated from mouse pancreas  

作　　者：Lisa Samuelson Natasha Wright David Allen Gerber 

机构地区：[1]不详

出　　处：《Stem Cell Discovery》2011年第3期44-53,共10页干细胞探索（英文）

摘　　要：In this study we have isolated and identified a progenitor cell population located in murine pancreatic tissue. This cell population has specific properties that make it different from previously described candidate pancreatic progenytor cell populations. It is located in the periductal region outside the islet architecture yet the cells have features consistent with endodermal development and endocrine functions within the islet. Cells are proliferative and capable of differentiation into pancreatic lineages expressing pancreatic associated transcription factors and proteins and maintaining the ability to produce insulin.In this study we have isolated and identified a progenitor cell population located in murine pancreatic tissue. This cell population has specific properties that make it different from previously described candidate pancreatic progenytor cell populations. It is located in the periductal region outside the islet architecture yet the cells have features consistent with endodermal development and endocrine functions within the islet. Cells are proliferative and capable of differentiation into pancreatic lineages expressing pancreatic associated transcription factors and proteins and maintaining the ability to produce insulin.

关 键 词：PANCREATIC PROGENITOR Diabetes SCA-1 MURINE PANCREAS 

分 类 号：R73[医药卫生—肿瘤]