Compilation and Analysis of Atherosclerosis Gene Expression Data  

作　　者：Michelle L. Booze Kathleen M. Eyster 

机构地区：[1]Division of Basic Biomedical Sciences, Sanford School of Medicine, The University of South Dakota, Vermillion, SD, USA

出　　处：《Advances in Biological Chemistry》2015年第2期142-150,共9页生物化学进展（英文）

摘　　要：The objective of this project was to search for consensus in differential gene expression data and in regulation of differentially expressed genes among DNA microarray studies of atherosclerotic vessels and plaque. Seventeen DNA microarray studies of atherosclerosis were analyzed. Only 19 genes were found to be differentially expressed in 3 or more of the studies. The nineteen genes belong to classic gene ontologies known to be involved in atherosclerosis: immunity and defense, metabolism, proteases, receptors, and signal transduction. Four bioinformatics programs (TRED, rVISTA, JASPAR, and Ariadne Pathways) were used to further analyze the promoter regions and common upstream regulators of the 19 genes. Twelve of the genes shared nine common upstream regulators, many of them known to affect atherosclerosis, and one possible new pathway was identified that may be involved in this disease.The objective of this project was to search for consensus in differential gene expression data and in regulation of differentially expressed genes among DNA microarray studies of atherosclerotic vessels and plaque. Seventeen DNA microarray studies of atherosclerosis were analyzed. Only 19 genes were found to be differentially expressed in 3 or more of the studies. The nineteen genes belong to classic gene ontologies known to be involved in atherosclerosis: immunity and defense, metabolism, proteases, receptors, and signal transduction. Four bioinformatics programs (TRED, rVISTA, JASPAR, and Ariadne Pathways) were used to further analyze the promoter regions and common upstream regulators of the 19 genes. Twelve of the genes shared nine common upstream regulators, many of them known to affect atherosclerosis, and one possible new pathway was identified that may be involved in this disease.

关 键 词：ATHEROSCLEROSIS JASPAR TRED rVISTA DNA MICROARRAY BIOINFORMATICS GENE Expression 

分 类 号：R73[医药卫生—肿瘤]