Structural Factors of Annonaceous Acetogenins and Their Semisynthetic Analogues Related with the Toxicity on Spodoptera frugiperda  

作　　者：Lilian Di Toto Blessing Florencia Budeguer Juan Ramos Alicia Bardón Sonia Diaz Margarita Brovetto Gustavo Seoane Adriana Neske 

机构地区：[1]Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, Argentina [2]Instituto de Química Física, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, Argentina [3]INQUINOA-CONICET, Tucumán, Argentina [4]Dpto de Química Orgánica, Fac de Química, UdelaR, Montevideo, Uruguay

出　　处：《Journal of Agricultural Chemistry and Environment》2015年第2期56-61,共6页农业化学和环境（英文）

摘　　要：Toxic and nutritional effects of annonaceous acetogenins and their semisynthetic analogues on Spodoptera frugiperda were evaluated. Structural modification of the natural ACG, blocking the OH flanking THF with MOM, allowed us to suggest the mode of action of ACG in the membrane. Our study emphasizes the role of the flanking OH and acetyl groups of THF with the membrane hydrophilic polar head groups. They are essential structural factors in the ACG that facilitate the intermolecular interaction that dehydrates the membrane and makes it potentially toxic against Spodoptera frugiperda.Toxic and nutritional effects of annonaceous acetogenins and their semisynthetic analogues on Spodoptera frugiperda were evaluated. Structural modification of the natural ACG, blocking the OH flanking THF with MOM, allowed us to suggest the mode of action of ACG in the membrane. Our study emphasizes the role of the flanking OH and acetyl groups of THF with the membrane hydrophilic polar head groups. They are essential structural factors in the ACG that facilitate the intermolecular interaction that dehydrates the membrane and makes it potentially toxic against Spodoptera frugiperda.

关 键 词：Annonaceous ACETOGENINS Polyphagous LEPIDOPTERAN TOXICITY NUTRITIONAL Alterations 

分 类 号：R73[医药卫生—肿瘤]