Nanomaterials and Cell Interactions: A Review  

作　　者：Tenderwealth Clement Jackson Bernard Opatimidi Patani Mary Blessed Israel 

机构地区：[1]Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Uyo, Nigeria [2]Medical Department, Nigerian AGIP Oil Company, Port Harcourt, Nigeria [3]Department of Biochemistry, University of Uyo, Uyo, Nigeria

出　　处：《Journal of Biomaterials and Nanobiotechnology》2017年第4期220-228,共9页生物材料与纳米技术（英文）

摘　　要：Nanotoxicology, a branch of bionanoscience focuses on the study of the hazardous interactions between nanomaterials and the ecosystem and ascertaining its consequent implications. Nanomaterial-cell interactions are dependent on numerous factors such as size, shape, type and surface coatings/charge of nanomaterials. These factors in association with cell membrane factors such as charge and formation of the protein corona influence the uptake and internalization of these particles leading to their potential toxicity. Understanding the different routes of exposure, their transport, behaviour and eventual fate is also of importance. Toxicities that occur to the living systems are consequences of various causes/dysfunctions such as ROS production, loss of membrane integrity, releases of toxic metal ions that bind with specific cell receptors and undergo certain conformations that inhibit normal cell function resulting in cytotoxicity, genotoxicity and possible cell necrosis. This paper attempts to review the available research pertaining to nanomaterial-cell interactions and their potential toxicity.Nanotoxicology, a branch of bionanoscience focuses on the study of the hazardous interactions between nanomaterials and the ecosystem and ascertaining its consequent implications. Nanomaterial-cell interactions are dependent on numerous factors such as size, shape, type and surface coatings/charge of nanomaterials. These factors in association with cell membrane factors such as charge and formation of the protein corona influence the uptake and internalization of these particles leading to their potential toxicity. Understanding the different routes of exposure, their transport, behaviour and eventual fate is also of importance. Toxicities that occur to the living systems are consequences of various causes/dysfunctions such as ROS production, loss of membrane integrity, releases of toxic metal ions that bind with specific cell receptors and undergo certain conformations that inhibit normal cell function resulting in cytotoxicity, genotoxicity and possible cell necrosis. This paper attempts to review the available research pertaining to nanomaterial-cell interactions and their potential toxicity.

关 键 词：NANOTOXICOLOGY NANOMATERIALS Cell CYTOTOXICITY OXIDATIVE STRESS GENOTOXICITY 

分 类 号：R73[医药卫生—肿瘤]