Antioxidant Protective Effects of the Resveratrol on the Cardiac and Vascular Tissues from Renal Hypertensive Rats  

作　　者：Joyce Cristina de Oliveira Carla Renata Kitanish Antonietto Angélica Cristina Scalabrini Talita Sanches Marinho Larissa Pernomian JoséWilson NCorrêa Carolina Baraldi Araujo Restini 

机构地区：[1]School of Nutrition,University of Ribeirao Preto,Ribeirao Preto,Brazil [2]School of Pharmaceutical Sciences,University of Ribeirao Preto,Ribeirao Preto,Brazil [3]Department of Physics and Chemistry,Faculty of Pharmaceutical Sciences from Ribeirao Preto,Laboratory of Pharmacology,University of Sao Paulo,Ribeirão Preto,Brazil [4]Federal University of Amazonas,Manaus,Brazil [5]School of Medicine,Animal Experimental Laboratory,University of Ribeirao Preto,Ribeirao Preto,Brazil

出　　处：《Open Journal of Medicinal Chemistry》2012年第3期61-71,共11页药物化学期刊（英文）

摘　　要：Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.

关 键 词：HYPERTENSION AORTA Superoxide RESVERATROL PHENYLEPHRINE Reactive Species of Oxygen(ROS) 

分 类 号：R73[医药卫生—肿瘤]