Synthetic Resveratrol Derivatives and Their Biological Activities: A Review  

作　　者：Ya Liu Yi Liu Hongfei Chen Xu Yao Yan Xiao Xianliang Zeng Qutong Zheng Yun Wei Chen Song Yinxiang Zhang Peng Zhu Juan Wang Xing Zheng 

机构地区：[1]University of South China, Hengyang, China [2]Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, China [3]Research Interest Group, University of South China, Hengyang, China

出　　处：《Open Journal of Medicinal Chemistry》2015年第4期97-105,共9页药物化学期刊（英文）

摘　　要：Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted extensive exploration due to its multiple biological activities, such as anticancer, antioxidant, cardiovascular protection, anti-inflammatory, antiviral, chemopreventive effect, neuroprotective effect, immunomodulation and so on. However, owing to its poor oral bioavailability, the application of resveratrol is greatly restricted. Because of that, a large amount of efforts had been made by researchers on designing its derivatives to obtain compounds with improved efficiency and low toxicity for developing more active drugs for clinical application. In this report, we review the current development of studying on resveratrol derivatives including their properties and activities. Additionally, this article also presents the synthetic routes of correlative resveratrol derivatives.Resveratrol, a naturally derived stilbene that exists in various foods and beverages, has attracted extensive exploration due to its multiple biological activities, such as anticancer, antioxidant, cardiovascular protection, anti-inflammatory, antiviral, chemopreventive effect, neuroprotective effect, immunomodulation and so on. However, owing to its poor oral bioavailability, the application of resveratrol is greatly restricted. Because of that, a large amount of efforts had been made by researchers on designing its derivatives to obtain compounds with improved efficiency and low toxicity for developing more active drugs for clinical application. In this report, we review the current development of studying on resveratrol derivatives including their properties and activities. Additionally, this article also presents the synthetic routes of correlative resveratrol derivatives.

关 键 词：ANTICANCER ANTIOXIDANT ANTI-INFLAMMATORY RESVERATROL DERIVATIVES STRUCTURE-ACTIVITY Relationship (SAR) 

分 类 号：R73[医药卫生—肿瘤]