supported by the National Natural Science Foundation of China(31271227,81161120551);the National Basic Research Program of China(2011CB503902)
SIRT1,a mammalian ortholog of yeast silent information regulator 2(Sir2),is an NAD+-dependent protein deacetylase that plays a critical role in the regulation of vascular function.The current study aims to investigate...
supported by the National Natural Science Foundation of China (31271227,91339201);the Beijing Nova Program (XX2013064);the National Basic Research Program of China (2011CB503902)
Calorie restriction(CR)is a dietary regime based on low calorie intake.CR without malnutrition extends lifespan in a wide range of organisms from yeast to rodents,and CR can prevent and delay the onset of age-related ...
Supported by National Natural Science Foundation of China(31271227,30721063,81161120551);National Basic Research Program of China(973 Program,2011CB503902,2011CB965203)
Objective To investigate the role of lysine-specific demethylase 1 (LSD1) in the process of THP-1 monocyte-to-macrophage differentiation. Methods Quantitative reverse transcription-polymerase chain reaction (qRT-...
supported by National Natural Science Foundation of China(31271227,31028005,31021091);National Basic Research Program of China (2011CB503902,2012BAI39B03)
Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the recruitment of leukocytes to the endothelium, which causes inflammation and initiation of atherosclerosis. We have previously shown that endo...
supported by the National Basic Research Program of China (Grant No. 2011CB503902);National Natural Science Foundation of China (Grant Nos. 31028005 and 31021091)
The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century. Mammalian sirtuin 1 (SIRT1) has been shown to decrease high-glucose-in...