国家自然科学基金(Y2006C31)

作品数：4被引量：5H指数：2
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相关作者：王建强宋林晨马淑涛更多>>
相关机构：山东大学更多>>
相关期刊：《中国药物化学杂志》《Chinese Chemical Letters》更多>>
相关主题：SYNTHESISCARBAMATEDERIVATIVESAZITHROMYCINMACROLIDE更多>>
相关领域：医药卫生理学生物学农业科学更多>>
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Synthesis and antibacterial activity of 4″-O-carbamoyl analogs of clarithromycin被引量：3
《Chinese Chemical Letters》2010年第3期257-260,共4页Xue Cui Shen Bo Jiao Shu Tao Ma 
supported by Major R&D Program of New Drugs-National S&T Key Special Subject of China (No.2009ZX09103-115);National Natural Science Foundation of China(No.20872081);Natural Science Foundation of Shandong(No.Y2006C31)
A series of novel 4'-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-suscepti...
关键词：Clarithromycin analogs 4″-O-carbamate SYNTHESIS Antibacterial activity Resistant bacteria 
Synthesis of novel 15-membered macrolide dimers
《Chinese Chemical Letters》2009年第8期931-934,共4页Shu Tao Ma Rui Xin Ma Rui Qing Xian Bo Jiao 
supported by the National Natural Science Foundation of China(No.2087208 1);Natural Science Foundation of Shandong(No.Y2006C3 1);Shandong Science and Technology Promotion Project(No.2005GG3202098).
A series of novel dimers of 15-membered macrolides was synthesized and evaluated. The dimers exhibited excellent activity against erythromycin-susceptible S. pneumonia, but did not show any improved activity against e...
关键词：MACROLIDE Azithromycin derivatives D/mers SYNTHESIS 
微波辐射快速合成喹诺酮类药物关键中间体7-卤代-6-氟-1-甲基-4-氧代-1,4-二氢-[1,3]硫氮杂环丁烷并[3,2-a]喹啉-3-羧酸乙酯(英文)
《中国药物化学杂志》2009年第3期214-217,共4页宋林晨 王建强 马淑涛 
National Natural Science Foundation of China(20872081);Natural Science Foundation of Shandong Province(Y2006C31);Science and Technology Development Project of Shandong Province(2005GG3202098)
采用微波辐射法简便、快速、高效地合成喹诺酮类药物关键中间体7-卤代-6-氟-1-甲基-4-氧代-1,4-二氢-[1,3]硫氮杂环丁烷并[3,2-a]喹啉-3-羧酸乙酯。中间产物及目标化合物的结构经IR、1H-NMR、MS谱和元素分析确证。结果表明在微波辐射下...
关键词：微波辐射法 三环喹诺酮 环化 
Synthesis of novel 15-membered macrolide derivatives被引量：2
《Chinese Chemical Letters》2008年第4期409-411,共3页Rui Qing Xian Shu Tao Ma Bo Jiao 
supported by NNSFC(No.20372043),Shandong Science and Technology Promotion Project(No.2005GG3202098);Natural Science Foundation of Shandong Province(No.Y2006C31).
In order to develop new antibiotics effective against resistant bacteria,a series of novel 15-membered macrolide derivatives were designed and synthesized by the modification of hydroxyl groups at C-11,C-12 and C-4＂ ...
关键词：MACROLIDE Azithromycin derivatives SYNTHESIS 4＂-Carbamate derivatives 
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