云南高校图书馆联盟文献共享服务平台- 国家重点基础研究发展计划(2011CB911002)

国家重点基础研究发展计划(2011CB911002): 作品数：14被引量：56H指数：4; 导出分析报告; 相关作者：王柯敏羊小海王青赵下雨谭誉宇更多>>; 相关机构：湖南大学中国科学院苏州大学中国科学院大学更多>>; 相关期刊：《中国肿瘤临床》《Science China Chemistry》《化学传感器》《科学通报》更多>>; 相关主题：DNA信号放大纳米金颗粒BASED_ONPOLYMERIZATION更多>>; 相关领域：理学医药卫生自动化与计算机技术生物学更多>>

DNA aptamer selected for specific recognition of prostate cancer cells and clinical tissues: 《Chinese Chemical Letters》2017年第6期1252-1257,共6页Zhi-Xiang Huang Qin Xie Qiu-Ping Guo Ke-Min Wang Xiang-Xian Meng Bao-Yin Yuan Jun Wan Yuan-Yuan Chen; supported by the National Natural Science Foundation of China(Nos.21175035,21275043,21190040);the National Basic Research Program(No.2011CB911002);the Hunan Province Science and Technology Project of China(No.2013FJ4042); Prostate cancer is the most common malignancy in men lack of efficient early diagnosis and therapeutics,calling for effective molecular probes.Herein,we performed cell-based systematic evolution of ligands by exponent...; 关键词：Aptamer Cell-SELEX Prostate cancer PC-3M Clinical tissues

Sensitive detection of DNA methyltransferase activity based on supercharged fluorescent protein and template-free DNA polymerization被引量：1: 《Science China Chemistry》2016年第7期809-815,共7页Daiqi Li Guoyan Lu Chunyang Lei Zhen Wang Lijun Li Zhou Nie Yan Huang Shouzhuo Yao; supported by the National Basic Research Program (2011CB911002);the National Natural Science Foundation of China (21190044, 21475037, 21222507, 21175036);the fundamental research funds for the central universities; DNA methylation, catalyzed by DNA methyltransferases(MTases), is a key component of genetic regulation, and DNA MTases have been regarded as potential targets in anticancer therapy. Herein, based on our previously dev...; 关键词：DNA methyltransferase supercharged fluorescent protein graphene oxide DNA polymerization

光助燃料电池的研究进展被引量：1: 《电化学》2016年第3期219-230,共12页张玲玲董绍俊; 国家自然科学基金项目(No.21375123);973项目(No.2011CB911002);科技部专项(No.2013YQ170585)资助; 化石燃料的大量开采和利用所导致的能源与环境问题是当今社会可持续发展必须面对的两大挑战.燃料电池通过电化学反应将燃料中的化学能直接转化为电能,是目前清洁高效的可再生能源转化装置.光助燃料电池将光响应成分引入到燃料电池中,可...; 关键词：燃料电池光电催化生物电催化能源转化

P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release被引量：4: 《Chinese Chemical Letters》2015年第10期1203-1208,共6页Yu-Jie Chang Xi-Zhen Liu Qing Zhao Xiao-Hai Yang Ke-Min Wang Qing Wang Min Lin Meng Yang; supported by the National Natural Science Foundation of China (Nos. 21190040, 21175035, 21375034);National Basic Research Program of China (No. 2011CB911002);International Science & Technology Cooperation Program of China (No. 2010DFB30300); A pH-sensitive controlled release system was proposed in this work, which consists of mesoporous silica nanoparticles（MSNs） functionalized on the pore outlets with poly（4-vinylphenybronic acid-co-2-（dimethylamino...; 关键词：pH-sensitive Mesoporous silica nanoparticles Nanovalve Polymer

A facile approach toward multicolor polymers:Supramolecular self-assembly via host-guest interaction: 《Chinese Chemical Letters》2014年第10期1318-1322,共5页Xiao-Hai Yang Fang Zhao Lei-Liang He Ke-Min Wang Jin Huang Qing Wang Jian-Bo Liu Meng Yang; supported by the National Natural Science Foundation of China(Nos.21190044,21175035);National Basic Research Program(No.2011CB911002);International Science & Technology operation Program of China(No.2010DFB30300); A one-step and facile strategy toward the construction of multicolor polymers via supramolecular selfassembly was proposed.Multicolor polymers were simply prepared by the self-assembly of adamantane-labeled fluorescei...; 关键词：Multicolor β-Cyclodextrin polymer Self-assembly Host-guest interaction

基于免标记发夹型探针和核酸外切酶Ⅲ的荧光信号放大DNA检测被引量：6: 《高等学校化学学报》2014年第8期1646-1651,共6页郭秋平赵下雨谢琴王柯敏万俊袁宝银谭誉宇; 国家自然科学基金重大项目(批准号:21190044)、国家自然科学基金(批准号:21175035);国家“九七三”计划项目(批准号:2011CB911002);科技部国际合作专项(批准号:2010DFB30300);湖南省科学技术项目(批准号:2013FJ4042)资助~~; 设计合成了一种长臂发夹型核酸探针,结合核酸外切酶Ⅲ水解反应建立了一种免标记荧光信号放大高灵敏检测DNA的新方法。当不存在靶DNA时, SYBR Green Ⅰ荧光染料能够嵌入发夹型探针的茎部而发出很强的荧光,而当存在靶DNA并与发夹型探针杂...; 关键词：发夹型探针核酸外切酶Ⅲ 免标记信号放大 DNA检测

Sensitive detection of DNA methyltransferase activity based on rolling circle amplification technology被引量：2: 《Chinese Chemical Letters》2014年第7期1047-1051,共5页Pei Liu Xiao-Hai Yang Qing Wang Jing Huang Jian-Bo Liu Ying Zhu Lei-Liang He Ke-Min Wang; supported by the National Natural Science Foundation of China(Nos.21190044 and 21175035);National Basic Research Program(No.2011CB911002);International Science&Technology operation Program of China(No.2010DFB30300); This work develops a fluorescence approach for sensitive detection of DNA methyltransferase activity based on endonuclease and rolling circle amplification （RCA） technique. In the presence of DNA adenine methylation...; 关键词：METHYLTRANSFERASE RCAD am MTase Dpn 1 FLUORESCENCE

功能纳米材料在肿瘤光学治疗中的应用被引量：28: 《中国肿瘤临床》2014年第1期18-26,共9页程亮汪超刘庄; 国家自然科学基金项目(编号:51302180;51222203;51002100;51132006);国家973项目(编号:2011CB911002;2012CB932601);江苏省自然科学基金(编号:BK20130005;BK20130305)资助~~; 目前在癌症的治疗中,药物化疗和手术对正常的组织易产生一定程度的损伤,且治疗效果有较大局限。肿瘤光学治疗主要采用近红外光有选择性地杀死肿瘤细胞,不会对正常的组织造成明显的不良作用。随着纳米材料和纳米科技的发展,肿瘤光学治疗...; 关键词：肿瘤光学治疗纳米材料光热治疗光动力治疗

A novel fluorescent detection for PDGF-BB based on dsDNA-templated copper nanoparticles被引量：3: 《Chinese Chemical Letters》2014年第1期9-14,共6页Xiao-Hai Yang Shan Sun Pei liu Ke-Min Wang Qing Wang Jian-Bo Liu Jin Huang Lei-Liang He; supported by the National Natural Science Foundation of China(Nos.21190041,21190044,21175035);National Basic Research Program(No.2011CB911002);Interna-tional Science&Technology operation Program of China(No.2010DFB30300); A novel method for the detection of PDGF-BB has been developed using double-strand DNA-copper nanoparticles （dsDNA-CuNPs） as fluorescent markers. This assay relies on the premise that the aptamer- based probe underg...; 关键词：Copper nanoparticles PDGF-BB Polymerization

人肝细胞性肝癌细胞株的高特异识别核酸适配体筛选被引量：5: 《科学通报》2013年第27期2745-2750,共6页郭秋平刘小丹谭誉宇王柯敏羊小海周玉叶玲赵下雨; 国家自然科学基金重大项目(21190041;21190044);国家自然科学基金(20905023);国家重点基础研究发展计划(2011CB911002);科技部国际合作专项(2010DFB30300);湖南省科学技术项目(2010SK3002;2013FJ4042)资助; 从分子水平上发展高特异和高灵敏的分子识别探针对肝癌的特异性识别和早期诊断具有非常重要的意义.本文以人肝细胞性肝癌细胞株Bel-7404为靶细胞株,人胆管细胞性肝癌细胞株QBC-939为对照细胞株,利用Cell-SELEX技术筛选得到4条与肝细胞...; 关键词：核酸适配体 Cell-SELEX 肝癌早期诊断

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