This work was supported by the National Natural Science Foundation of China (No 81072637). We also thank Ms Na LUO of the University of Hong Kong for her editorial assistance with this paper.
Aim: The augmentation of late sodium current (/Na.L) not only causes intracellular Na^+ accumulation, which results in intracellular Ca^2+ overload via the reverse mode of the Na^+/Ca^2+ exchange current (reve...