国家自然科学基金(30672029)

作品数:3被引量:10H指数:2
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相关作者:刘薇许力虞雪融李旭黄宇光更多>>
相关机构:北京协和医院更多>>
相关期刊:《Chinese Medical Journal》《协和医学杂志》《Chinese Medical Sciences Journal》更多>>
相关主题:蛋白质激酶CA2+钙调蛋白慢性压迫损伤疼痛行为更多>>
相关领域:医药卫生生物学更多>>
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Analgesic effect of gabapentin in a rat model for chronic constrictive injury被引量:3
《Chinese Medical Journal》2011年第24期4304-4309,共6页MA Lu-lu LIU Wei HUANG Yu-guang YANG Nan ZUO Ping-ping 
This research is supported by a grant from the National Natural Science Foundation of China (No. 30672029).
Background Gabapentin has been widely and successfully used in the clinic for many neuropathic pain syndromes since last decade, however its analgesic mechanisms are still elusive. Our study was to investigate whether...
关键词:neuropathic pain GABAPENTIN ANALGESIA Ca^2+ /calmoduhn-dependent protein kinase II 
PSD95 Gene Specific siRNAs Attenuate Neuropathic Pain through Modulating Neuron Sensibility and Postsynaptic CaMKIIα Phosphorylation被引量:1
《Chinese Medical Sciences Journal》2011年第4期201-207,共7页Le Shen Xu Li Wen Chen Li Xu Wei Liu Xue-rong Yu Yu-guang Huang 
Supported by National Natural Science Foundation of China (30672029, 30872436);Central Committee Foundation of Health Care Program (B2009B076)
Objective To observe the effects of PSD95 gene specific siRNAs on neuropathic pain relief, neuron viability, and postsynaptic calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) phosphorylation in vitro and in...
关键词:PSD95 SIRNAS neuropathic pain glutamate excitotoxicity calcium/calmodulin- dependent protein kinase IItt 
突触后致密物蛋白质95基因沉默及对神经病理性疼痛大鼠疼痛行为的干预被引量:6
《协和医学杂志》2011年第4期343-349,共7页李旭 申乐 许力 刘薇 虞雪融 黄宇光 
国家自然科学基金(30672029);中央保健专项基金(B2009B076)
目的评估小干扰RNA(small interfering RNA,siRNA)对突触后致密物蛋白质95(postsynaptic density protein95,PSD-95)基因的沉默效率及PSD-95基因沉默对谷氨酸诱导的神经细胞毒性与信号转导的影响,观察用RNA干扰(RNA interference,RNAi)...
关键词:神经病理性疼痛 突触后致密物蛋白质95 谷氨酸兴奋性中毒 Ca2+/钙调蛋白依赖的蛋白质激酶IIα 慢性压迫损伤 小干扰RNA 
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