supported by grants from the Ministry of Science and Technology of China (2012CB721005, 2012AA02A706, 2011ZX08009-001, 2012AA022107);the National Natural Science Foundation of China (31070070, 31121064);Ministry of Education of China (20110073110048);the SJTU-UM Collaborative Program
The highly potent antitumor agent ansamitocin P3 is a macrolactam isolated from Actinosynnema pretiosum ATCC 31565. A 120-kb DNA fragment was previously identified as the ansamitocin biosynthetic gene cluster, and con...