国家自然科学基金(30770111)

作品数：4被引量：24H指数：3
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相关作者：黄莉莉郭晓奎更多>>
相关机构：交通大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Cell Research》《国际生物制品学杂志》更多>>
相关主题：PATIENTSMICROBIOTASPUTUMLEPTOSPIRACOMPARATIVE更多>>
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New microbiota found in sputum from patients with community-acquired pneumonia被引量：3
《Acta Biochimica et Biophysica Sinica》2013年第12期1039-1048,共10页Chunyan Chen Tian Shen Fei Tian Ping Lin Qingtian Li Zelin Cui Yajuan Zhang Min Xue Jing Ye Xiaokui Guo Yuhua Zhou 
This work was supported by grants from the National Natural Science Foundation of China （30770111, 30900051, 30970125）, the National Key Program for Infectious Diseases of China （2008ZX 10004-002, 2008ZX 10004-009, and 2009ZX10004-712）, and the Program of Shanghai Subject Chief Scientist （09XD 1402700）.
Community-acquired pneumonia （CAP） is a major concern in hospitals and the bacterial community of which has not been systemically discussed yet. Sputum from patients in the acute stages is a kind of accessible sampl...
关键词：16s ribosomal DNA MICROBIOTA community-acquired pneumonia PYROSEQUENCING SPUTUM 
Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601被引量：10
《Cell Research》2011年第8期1210-1229,共20页Yi Zhong Xiao Chang Xing-Jun Cao Yan Zhang Huajun Zheng Yongzhang Zhu Chengsong Cai Zelin Cui Yunyi Zhang Yuan-Yuan Li Xiu-Gao Jiang Guo-Ping Zhao Shengyue Wang Yixue Li Rong Zeng Xuan Li Xiao-Kui Guo 
We thank Professor M Picardeau for the gift ofL. interrogans strain IPAV and Bao-Yu Hu and Yang Yang for the support in performing bacteria culture. We also thank Dr Junwei Yang for suggestions in revising the manuscript. We thank the genome sequencing team at Chinese Human Genome Center at Shanghai for their assistance. This work was supported in part by grants from the National Natural Science Foundation of China （30770111, 30900051 and 30970125）, the National Key Program for Infectious Diseases of China （2008ZX10004 and 2009ZX10004）, the Program of Shanghai Subject Chief Scientist （09XD 1402700） and the Program of Shanghai Research and Development （10JC 1408200）.
The virulence-attenuated Leptospira interrogans serovar Lai strain IPAV was derived by prolonged laboratory passage from a highly virulent ancestral strain isolated in China. We studied the genetic variations of IPAV ...
关键词：GENOME PROTEOME LEPTOSPIRA VIRULENCE MUTATION 
Analysis of the microbiota of sputum samples from patients with lower respiratory tract infections被引量：8
《Acta Biochimica et Biophysica Sinica》2010年第10期754-761,共8页Yuhua Zhou Ping Lin Qingtian Li Lizhong Han Huajun Zheng Yanxia Wei Zelin Cui Yuxing Ni Xiaokui Guo 
This work was supported by grants from the National Natural Science Foundation of China （30770111, 30900051, and 30970125）, the National Key Program for Infectious Diseases of China （2008ZX10004 and 2009ZX10004）, the Program of Shanghai Subject Chief Scientist （09XD1402700）, and the Program of Shanghai Research and Development （10JC 1408200）.
Sputum is the most common sample collected from patients suffering from lower respiratory tract infections and it is crucial for the bacterial identification of these infections. In this study, we enrolled 101 sput...
关键词：16S ribosomal DNA lower respiratoryinfection MICROBIOTA pyrosequence SPUTUM 
钩端螺旋体研究进展被引量：3
《国际生物制品学杂志》2010年第2期66-70,共5页黄莉莉 郭晓奎(综述) 
国家自然科学基金（30770111）;“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项“十一五”计划（2008ZX1004.002、2008ZX1004-009、2009ZX10607）
钩端螺旋体病是一种由致病性钩端螺旋体感染引起的人畜共患病。研究发现，致病性钩端螺旋体具有独特的基因组结构，可分为不同的血清型或基因组种。钩端螺旋体的传播受菌株、宿主免疫力以及环境等多种因素的影响。钩端螺旋体具有强大的...
关键词：钩端螺旋体属 钩端螺旋体病 毒力 诊断 疫苗 
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