国家自然科学基金(81171495)

作品数:7被引量:37H指数:4
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相关作者:李家文皮先明贺琪陈宏翔石全更多>>
相关机构:华中科技大学浠水县中医院湖北省中医院郑州大学更多>>
相关期刊:《实用医学杂志》《中华皮肤科杂志》更多>>
相关主题:白细胞介素-17ITSIL-3RELATIONSHIPP38_MAPK更多>>
相关领域:医药卫生更多>>
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Opacity Proteins of Neisseria Gonorrhoeae in Lipooligosaccharide Mutants Lost Ability to Interact with Neutrophil-restricted CEACAM3(CD66d)
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第3期344-349,共6页张颂 涂亚庭 蔡华华 丁红辉 李俏 何应霞 刘欣欣 王新 胡枫 陈铁 陈宏翔 
partly supported by grants from National Natural Science Foundation of China(No.81171495 and No.81271780);the Youth Chenguang Project of Science and Technology of Wuhan City of China(No.2015071704011621)
Lipooligosacharide(LOS) of Neisseria gonorrhoeae(gonococci, GC) is involved in the interaction of GC with host cells. Deletion of the alpha-oligosaccharide(alpha-OS) moiety of LOS(lgt F mutant) significantly i...
关键词:Neisseria gonorrhoeae chemiluminescence alpha-oligosaccharide opacity proteins 
中重度寻常型银屑病患者治疗前后外周血白细胞介素-37、促炎因子的表达变化及意义被引量:10
《实用医学杂志》2016年第8期1261-1264,共4页贺琪 皮先明 石全 陈宏翔 李家文 杨迎香 
国家自然科学基金资助项目(编号:81171495;81271765)
目的:通过研究中重度寻常型银屑病(PV)患者治疗前后外周血白细胞介素(IL)-37、干扰素(IFN)-γ、IL-4和IL-17的表达水平探索IL-37在银屑病中的表达变化及意义。方法:38例PV患者(银屑病组)口服阿维A治疗8周,应用PASI评分评估病情,并检测其...
关键词:银屑病 阿维A 白细胞介素-37 干扰素-Γ 白细胞介素-17 
microRNA-155在寻常型银屑病中的表达及意义被引量:6
《实用医学杂志》2016年第6期900-903,共4页贺琪 皮先明 石全 李家文 杨迎香 陈宏翔 
国家自然科学基金资助项目(编号:81171495;81271765)
目的:探讨micro RNA-155(mi R-155)在寻常型银屑病中的表达及意义。方法:采用Taq Man探针实时荧光定量聚合酶链式反应(q RT-PCR)检测35例寻常型银屑病患者皮损区(皮损组)和非皮损区(非皮损组)中的mi R-155表达水平,并与30例正常对照(对...
关键词:MIR-155 寻常型银屑病 TAQMAN探针 白细胞介素-17 
Lipoxin A4 Inhibits Lipopolysaccharide-induced Production of Inflammatory Cytokines in Keratinocytes by Up-regulating SOCS2 and Down-regulating TRAF6被引量:1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2015年第3期426-431,共6页胡枫 冯爱平 刘欣欣 张颂 徐俊涛 王新 钟雪莲 何蒙文 陈宏翔 
supported by grants from the National Natural Science Foundation of China(No.81171495,No.81271765,and No.81400970)
Liopxin A4(LXA4) is considered to be a crucial modulator in the inflammatory responses. In the present study, we aimed to study the effect of LXA4 on the inflammatory cytokines production induced by lipopolysacchar...
关键词:KERATINOCYTE inflammatory cytokine LXA4 SOCS2 TRAF6 NF-κB 
氨基酮戊酸光动力疗法治疗硬化萎缩性苔藓的疗效观察被引量:7
《中华皮肤科杂志》2014年第6期433-434,共2页陈静 李振鲁 朱雪峰 吴华娟 王莉 王豫平 
国家自然科学基金(81171495)
目的观察氨基酮戊酸光动力疗法治疗女阴硬化萎缩性苔藓的疗效和安全性。方法采用开放性,非对照性临床研究,受试者每两周进行1次氨基酮戊酸光动力治疗,治疗2~4次,于治疗前,治疗后2、4、8周各随访1次,进行疗效和安全性评价。结果共...
关键词:硬化萎缩性苔藓 外阴 氨基酮戊酸 光化学疗法 
IL-36 Cytokine Expression and Its Relationship with p38 MAPK and NF-κB Pathways in Psoriasis Vulgaris Skin Lesions被引量:12
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2013年第4期594-599,共6页贺琪 陈宏翔 李雯 吴艳 陈善娟 岳青 肖敏 李家文 
supported by grants from the National Natural Science Foundation of China(No.30972654,No.81101191,No.81271765 and No.81171495)
Summary: This study examined the correlation of the expression of interleukin-36 (IL-36), a novel member of interleukin-1 (IL-1) family, with p38 mitogen-activated protein kinase (p38 MAPK) and nu clear factor-...
关键词:interleukin-36 p38 mitogen-activated protein kinase nuclear factor-kappa B psoriasisvulgaris 
Expression of IRF-4 and IBP in Skin Lesions of Patients with Psoriasis Vulgaris被引量:1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2012年第2期287-290,共4页倪安红 陈宏翔 吴艳 李雯 陈善娟 李家文 
supported by grants from the National Natural Sciences Foundation of China(No.30972654and No.81171495)
The expression of the interferon regulatory factor 4 (IRF-4) and the IRF-4-binding protein (IBP) in psoriatic skin lesions was investigated. The expression of IRF-4 and IBP in skin lesions of 20 patients with psoriasi...
关键词:PSORIASIS IRF-4 IBP 
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