国家自然科学基金(21271012)

作品数：6被引量：10H指数：2
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相关作者：杨晓达肖茹月牛霞夏青张悦更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《中国科学：化学》更多>>
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钒配合物的药理作用和理性药物设计被引量：4
《中国科学：化学》2017年第2期162-171,共10页董雅琼 牛霞 肖茹月 张悦 夏青 杨晓达 
国家自然科学基金(编号:21571006,21271012);方正创新药物基金支持项目资助
自19世纪90年代以来,钒配合物的药物发现及其基础研究有了很大的进展,但仍然存在很多亟待解决的问题.本文综述了钒配合物的抗肿瘤、抗糖尿病作用和分子机制,及其潜在新作用——抗阿尔茨海默症的作用,也介绍了钒配合物的毒性作用及其机...
关键词：钒配合物 糖尿病 阿尔茨海默症 PPAR AΒ 
Vanadyl complexes work with cinnamaldehyde in promoting cell viability under the β-amyloid burden in SH-SY5Y neural cells被引量：2
《Journal of Chinese Pharmaceutical Sciences》2016年第10期754-763,共10页李雪 白力丹 董雅琼 常青 武睿 章京 杨晓达 
National Natural Science Foundation of China(Grant No.21571006 and 21271012)
The Alzheimer＇s disease （AD） is one of the common cognitive disorders in the elderly. AD shares some similar pathological characters with diabetes mellitus （DM）, suggesting potential application of anti-diabetic ...
关键词：Alzheimer＇s disease Β-AMYLOID SH-SY5Y cells VANADIUM CINNAMALDEHYDE 
Cinnamaldehyde promotes mitochondrial function and reduces Aβ toxicity in neural cells被引量：3
《Journal of Chinese Pharmaceutical Sciences》2016年第8期605-613,共9页Lidan Bai Xue Li Qing Chang Rui WU Jing Zhang Xiaoda Yang 
National Natural Science Foundation of China(Grant No.21571006 and 21271012);Beijing Natural Science Foundation(Grant No.7164308)
Cinnamon and its major active component, cinnamaldehyde, have been shown to be neuroprotective in models of Alzheimer＇s disease （AD）. To further investigate the mechanism of cinnamaldehyde, we investigated the effe...
关键词：Alzheimer＇s disease Aβ oligomers MITOCHONDRIA CINNAMALDEHYDE 
The long-term toxicity and hypoglycemic effect of vanadyl complexes on non-diabetic and type Ⅱ diabetic mice被引量：1
《Journal of Chinese Pharmaceutical Sciences》2015年第11期734-743,共10页王子维 王娜 黄美玲 杨晓达 
National Natural Science Foundation of China(Grant No.21271012)
Vanadium compounds are promising anti-diabetic agents. However, the concern in the toxicity, especially the long-term renal side effect along with diabetic status, is restricting the further development of this metal ...
关键词：Bis（（5-hydroxy-4-oxo-4H-pyran-2-yl） methyl 2-hydroxy-benzoatato） oxovanadium VANADIUM Diabetes Long-term toxicity 
Vanadium regulates HSP60-induced IL-6 release from RAW264.7 cells in a dose-dependent manner
《Journal of Chinese Pharmaceutical Sciences》2015年第1期28-33,共6页郭巍 杨晓达 
National Natural Science Foundation of China(Grant No.21271012)
Vanadium compounds are promising anti-diabetic agents. However, the underlying mechanisms have not been fully elucidated. Inflammation and auto-immune disorders play important roles in the progresses of both type Ⅰ a...
关键词：Vanadyl ions Heat shock protein 60 INTERLEUKIN-6 
Combination of vitamin C and zinc gluconate prevented vanadium-induced tight junction leakage of MDCK cell monolayer
《Journal of Chinese Pharmaceutical Sciences》2013年第5期403-408,共6页许智涵 王新一 肖茹月 杨晓达 
National Natural Science Foundation of China(Grant No.21271012);Research Fund for the Doctoral Program of Higher Education of China(Grant No.20090001110068)
The tight junction disorder plays an important role in the pathological process of many chronic diseases, and is becoming a major concern for the clinical application of metal drugs, i.e. anti-diabetic vanadium compou...
关键词：Zinc gluconate Vitamin C Tight junction Oxidative damage Intracellular calcium 
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