To develop a C. elegans model of amyotrophic lateral sclerosis (ALS) and to evaluate the role of autophagy in the disease. Methods: Stable transgenic worms expressing the G93A mutant form of Cu,Zn-superoxide dismut...
supported by the National Natural Science Foundation of China(No.39070925);Shanghai International Science and Technology Coopera-tion Program(No.075407066);National High Technology Research and Development Program of China(No.2006AA02A408)
Type II DNA topoisomerases(Tops)are ATP-dependent enzymes that catalyze topological transformations of genomic DNA by the transport of one DNA double helix through another.In mammals,there are 2 isoforms of DNA Top ...