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国家自然科学基金(30772650): 作品数：4被引量：0H指数：0; 导出分析报告; 相关作者：邹晓民徐萍周博王超牛彦更多>>; 相关机构：北京大学中国医学科学院北京协和医学院更多>>; 相关期刊：《Journal of Chinese Pharmaceutical Sciences》更多>>; 相关主题：INHIBITORSSYNTHESISPROTEASOMEMIDIINTERMEDIATES更多>>; 相关领域：医药卫生更多>>

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Synthesis of acyclic analogs of Syringolin A as potential 20S proteasome inhibitors: 《Journal of Chinese Pharmaceutical Sciences》2010年第6期423-435,共13页袁悦邹晓民牛彦许凤荣牟科周博王超李勇剑杨冠宇徐萍; National Natural Science Foundation of China (Grant No.20772008 and 30772650); A series of acyclic analogs of natural product Syringolin A （SylA） were designed and synthesized during our synthetic efforts for SylA. These acyclic analogs were prepared through a seven-step linear strategy, with ...; 关键词：Syringolin A 20S proteasome Peptidyl vinyl amide

Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors: 《Journal of Chinese Pharmaceutical Sciences》2010年第5期341-345,共5页周博牛彦邹晓民许凤荣袁悦王超高海飞刘鹏徐萍; National Natural Science Foundation of China (Grant No.20772008 and 30772650); Based upon the crystal structure of a previously reported fragment hit that binds to Corresponding author. β-secretase, a novel series of non-peptidic small-molecule β-secretase inhibitors, namely hexahydropyrimidin...; 关键词：β-Secretase inhibitors Hexahydropyrimidin-5-ols Structure-based drug design Computer-aided drug design

Efficient synthesis of terminal α,β-unsaturated ketones as the intermediates of the proteasome epoxyketone inhibitors via Weinreb amide: 《Journal of Chinese Pharmaceutical Sciences》2009年第1期33-36,共4页吕杨邹晓民牟科傅翌秋马超周博徐萍; National Natural Science Foundation of China (Grant No. 30772650 and 20772008); Peptidyl epoxyketones were potential antitumor agents due to their 20S proteasome inhibitory activities. Based on their structures and special inhibitory mechanism, a series of compounds were designed by linking the e...; 关键词：Epoxyketone SYNTHESIS α β-Unsaturated ketone Weinreb amide

Synthesis and activity of hydroxyethylene peptidomimetic inhibitors of humanβ-secretase: 《Journal of Chinese Pharmaceutical Sciences》2008年第3期215-220,共6页马超王月华杨晓鸣邹晓民吕杨杜冠华徐萍; National Natural Science Foundation of China(Grant No.30772650 and 20772008).; A series of β-secretase peptidomimetic inhibitors with Leu＊Ala hydroxyethylene dipeptide isostere were synthesized and their β-secretase inhibitory activities were measured. The most potent compound N9 showed an in...; 关键词：β-Secretase inhibitors Hydroxyethylene isostere SYNTHESIS Bioactivity

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