国家自然科学基金(30772626)

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相关作者：姚书扬周玥更多>>
相关机构：扬子江药业集团上海海尼药业有限公司更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》更多>>
相关主题：AMINOALDEHYDESVINYLSTUDYPEPTIDE更多>>
相关领域：医药卫生更多>>
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Study on the dipeptide vinyl sulfonamide derivatives as proteasome inhibitor
《Journal of Chinese Pharmaceutical Sciences》2016年第6期408-418,共11页姚书扬 周玥 
Natural Science Foundation of China for the financial support(Grant No.30772626)
On the basis of the Michael-addition mechanism of classical proteasome inhibitors, six dipeptide vinyl sulfonamide and dipeptide vinyl sulfonate derivatives were designed and synthesized. Moreover, an efficient method...
关键词：Proteasome inhibitor Dipeptide vinyl sulfonamides Wittig-Horner reaction g-Amino vinyl sulfonamide 
Study of the prodrugs of peptide aldehydes as proteasome inhibitors
《Journal of Chinese Pharmaceutical Sciences》2012年第1期21-27,共7页Li-Qiang Han Yu-An Zhang Shu-Yang Yao Bo Xu Ze-Mei Ge Jing-Rong Cui Run-Tao Li 
National Natural Science Foundation of China (Grant No.30772626)
To improve the stability of peptide aldehyde proteasome inhibitors, four peptide cycloacetal derivatives and two peptide heterocycle compounds were designed and synthesized. Their proteasome inhibition and in vitro an...
关键词：Proteasome inhibitor ANTICANCER Peptide acetal derivative Prodrug principle 
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