国家自然科学基金(30271558)

作品数:5被引量:12H指数:2
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相关作者:刘琳琳肖瑛任进更多>>
相关机构:中国科学院更多>>
相关期刊:《Acta Pharmacologica Sinica》《中国药物与临床》《毒理学杂志》更多>>
相关主题:CYTOCHROME_P450肝脏乙醇中毒乙醇脱氢酶MEDIATE更多>>
相关领域:医药卫生生物学更多>>
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ROS generated by CYP450, especially CYP2E1, mediate mitochondrial dysfunction induced by tetrandrine in rat hepatocytes被引量:5
《Acta Pharmacologica Sinica》2013年第9期1229-1236,共8页Xin-ming Qi Ling-ling Miao Yan Cai Li-kun Gong Jin Ren 
This work was supported by National Natural Science Foundation of China (No 30271558); Key projects of National Science and Technology Pillar Program (2012ZX09301001-006 and 2012zx09302003) and the Public Service Platform Project of Shanghai Science and Technology Committee (11DZ2292500).
Aim: Tetrandrine, an alkaloid with a remarkable pharmacological profile, induces oxidative stress and mitochondrial dysfunction in hepatocytes; however, mitochondria are not the direct target of tetrandrine, which pr...
关键词:TETRANDRINE MITOCHONDRIA reactive oxygen species cytochrome P450 
Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis被引量:1
《Acta Pharmacologica Sinica》2005年第6期737-744,共8页Lin-linLIU Li-kunGONG Xin-mingQI YanCAI HuiWANG Xiong-feiWU YingXIAO JinREN 
project supported by the National Natural Science Foundation of China (№ 30271558).
Aim: Correlation of cytochrome P450 (CYPs) with preneoplastic changes in the early stage of hepatocarcinogenesis is still unclear. To detect the expression of carcinogen-metabolizing related microsomal P450 enzymes, n...
关键词:cytochrome P450 preneoplastic changes hepatocarcinogensis 
细胞色素P450酶在化学物质诱导肝脏癌变作用及研究现状
《毒理学杂志》2004年第S1期313-317,共5页刘琳琳 任进 
国家自然科学基金(30271558)
关键词:细胞色素P450酶 化学物诱导肝癌 癌变早期 
乙醇中毒的最新研究进展被引量:6
《毒理学杂志》2004年第S1期321-323,共3页肖瑛 任进 
国家自然科学基金资助(30271558)
关键词:乙醇中毒 乙醇依赖 乙醇脱氢酶 
化学物质导致肝脏早期癌变的相关机制研究进展
《中国药物与临床》2004年第5期325-329,共5页刘琳琳 任进 
国家自然科学基金资助项目(30271558)
关键词:化学致癌物质 肝癌 病因学 发病机制 细胞凋亡 动物模型 
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