国家重点基础研究发展计划(2009CB941101toJL)

作品数：2被引量：26H指数：2
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Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation被引量：14
《Cell Research》2013年第1期92-106,共15页Jing Jiang Wenjian Lv Xiaoying Ye Lingbo Wang Man Zhang Hui Yang Maja Okuka Chikai Zhou Xuan Zhang Lin Liu Jinsong Li 
Induced pluripotent stem （iPS） cells generated using Yamanaka factors have great potential for use in autologous cell therapy. However, genomic abnormalities exist in human iPS cells, and most mouse iPS cells are no...
关键词：somatic reprogramming genomic stability TELOMERE Zscan4 tetraploid complementation iPS cells 
Haploid embryonic stem cells:an ideal tool for mammalian genetic analyses被引量：13
《Protein & Cell》2012年第11期806-810,共5页Linyu Shi Hui Yang Jinsong Li 
supported by grants from the Ministry of Science and Technology of China(No.2009CB941101 to J.L.);the "Strategic Priority Research Program" of the Chinese Academy of Sciences(No.XDA01010403 to J.L.).
Identification of the function of all genes in the mammalian genome is critical in understanding basic mechanisms of biology.However,the diploidy of mammalian somatic cells has greatly hindered efforts to elucidate th...
关键词：haploid embryonic stem cells parthenogenetic embryos androgenetic embryos genetic screening DIPLOID genomic imprinting 
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