国家重点基础研究发展计划(2007CB815800)

作品数:6被引量:9H指数:1
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相关作者:林浴霜陈冬艳张红卫范秋声张伟更多>>
相关机构:山东大学中国科学院南开大学更多>>
相关期刊:《Science Bulletin》《Science China(Life Sciences)》《Cell Research》《中国科学:生命科学》更多>>
相关主题:AMPHIOXUS进化文昌鱼BASALWAY更多>>
相关领域:生物学农业科学医药卫生自然科学总论更多>>
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Critical role of Toll-like receptor signaling in NK cell activation
《Chinese Science Bulletin》2012年第24期3192-3202,共11页GUO Qie ZHANG Cai 
supported by the National Natural Science Foundation of China (90713033, 30901307, and 30772497);the National Basic Research Program of China (2007CB815800)
Toll-like receptors (TLRs) and NK cell receptors are the most important receptor superfamilies in innate immunity. TLRs act as the sensor of external pathogens, while NK cells detect alterations in endogenous protein ...
关键词:TOLL样受体 NK细胞 信号通路 活化 免疫反应 细胞受体 适应性反应 微生物感染 
文昌鱼免疫防御相关组织、细胞及基因研究被引量:1
《中国科学:生命科学》2011年第12期1155-1161,共7页林浴霜 陈冬艳 张伟 蔡召平 陈忠科 张宁 毛炳宇 张红卫 
国家自然科学基金(批准号:30570967,30671072,30700434);山东省自然科学基金(批准号:Y2007D20);国家重点基础研究发展计划(批准号:2007CB815800,2007CB947100)资助项目
文昌鱼不仅对于进化学的研究至关重要,在比较免疫学研究中也是一种重要的模式生物.研究文昌鱼免疫相关组织、细胞和基因对了解脊椎动物免疫防御系统的进化十分重要.本文利用电子显微镜对文昌鱼免疫相关组织和细胞的超微结构进行了研究....
关键词:文昌鱼 表皮 消化道 巨噬细胞 免疫 进化 
Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates被引量:5
《Cell Research》2011年第10期1410-1423,共14页Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu 
This work was supported by grants from the National Basic Research Program (2007CB815800 and 2011CB946101), the State High-Tech Development Project (2008AA092603), International S&T Cooperation Program from the Ministry of Science and Technology of China (2007DFA30840), the Ministry of Education (0107), and the National Natural Science Foundation of China (30901305, 30730089), and the Fundamental Research Funds for the Central Universities (1 l lgzdl6). Anlong Xu is recipient of "Outstanding Young Scientist Award" from the National Natural Science Foundation of China.
The MyD88-independent pathway, one of the two crucial TLR signaling routes, is thought to be a vertebrate innovation. However, a novel Toll/interleukin-1 receptor (TIR) adaptor, designated bbtTICAM, which was identi...
关键词:TLR TICAM MyD88-independent pathway innate immunity evolution 
Identification and expression of amphioxus AmphiSmad1/5/8 and AmphiSmad4被引量:1
《Science China(Life Sciences)》2011年第3期220-226,共7页YU XueSong LI JianWei LIU Hui LI XiaoDan CHEN ShangWu ZHANG HongWei XU AnLong 
supported by the National Basic Research Program of China(Grant No. 2007CB815800);the National High Technology Research and Development Program of China(Grant No. 2006330004104456);the National Natural Science Foundation of China(Grant Nos. 30300264,30270693 and 30570967)
Smad family proteins are identified as intracellular signal mediators of the TGF-β superfamily.In this study,we identified two novel members of the Smad family,termed as AmphiSmad1/5/8 and AmphiSmad4,from Chinese amp...
关键词:AMPHIOXUS SMAD AmphiSmad1/5/8 AmphiSmad4 expression patterns ORGANOGENESIS dorsal-ventral patterning 
关于青岛文昌鱼SoxB2和SoxC基因的研究:进化保守性分析被引量:2
《中国科学(C辑)》2009年第5期469-478,共10页林浴霜 陈冬艳 范秋声 张红卫 
国家自然科学基金(批准号:30700434和30671072);山东省自然科学基金(批准号:Y2007D20);山东省优秀中青年科学家科研奖励基金(批准号:2006BS02009);国家重点基础研究发展计划(批准号:2007CB815800和2007CB947100)资助项目
大多数Sox基因在细胞命运决定和分化过程中起着重要的作用.本研究分离了青岛文昌鱼(Branchiostoma belcheri)的SoxB2和SoxC基因,对其预测的蛋白序列进行了序列比对、进化树分析以及基因时空表达分析.结果显示,文昌鱼SoxB2和SoxC虽然在...
关键词:文昌鱼 SoxB2 SoxC 神经胚形成 性腺 免疫 进化 
Characterization and developmental expression of AmphiMef2 gene in amphioxus
《Science China(Life Sciences)》2007年第5期637-641,共5页ZHANG Ying WANG LiFeng SHAO Ming ZHANG HongWei 
Supported by the National Natural Science Foundation of China (Grant Nos. 30270693 and 30570967);the Ministry of Science and Technology of China (Grant No. 2007CB815800)
Myocyte enhancer factor 2 proteins are members of MADS family of transcription factors, which can control the expression of muscle-specific genes in vertebrates. However, not all Mef2 genes are es-sential for muscle d...
关键词:AmphiMef2  amphioxus  DEVELOPMENTAL expression  myogenesis  preoral PIT 
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