国家自然科学基金(81273430)

作品数：8被引量：24H指数：2
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相关作者：郭跃伟梁林富更多>>
相关机构：中国科学院中南林业科技大学锦州医科大学更多>>
相关期刊：《Natural Products and Bioprospecting》《中国海洋药物》《Chinese Herbal Medicines》《Chinese Journal of Chemistry》更多>>
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涠洲岛沐浴角骨海绵Spongia officinalis的化学成分研究
《中国海洋药物》2017年第4期1-5,共5页孙冬宇 姚励功 韩冠英 郭跃伟 
国家自然科学基金项目(81520108028,81273430,41306130,81302692,41676073,81603022,81302681);山东省自然科学基金项目(U1406402);上海市科委基金项目(14431901100,15431901000);新药研究国家重点实验室项目(SIMM1501ZZ-03)资助
目的研究采自广西涠洲岛的沐浴角骨海绵Spongia officinalis的化学成分。方法利用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备HPLC等色谱技术对其化学成分进行分离、纯化;通过NMR、MS方法,结合与文献报道的数据的比对,对化合物的结...
关键词：沐浴角骨海绵 化学成分 C21呋喃萜 
5-Alkylpyrrole-2-carboxaldehyde derivatives from the Chinese sponge Mycale lissochela and their PTP1B inhibitory activities被引量：2
《Chinese Chemical Letters》2017年第6期1190-1193,共4页Duo-Qing Xue Hai-Li Liu Si-Han Chen Ernesto Mollo Margherita Gavagnin Jia Li Xu-Wen Li Yue-Wei Guo 
financially supported by the National Natural Science Foundation of China(Nos.41476063,81520108028,81273430,41306130 81302692,41676073,81603022);SCTSM Project from Shanghai Science and Technology Committee,Shanghai,China(Nos.14431901100,15431901000);The project from Institutes for Drug Discovery and Development,Chinese Academy of Sciences,China(No.CASIMM0120152039);the SKLDR/SIMM Projects from Shanghai Institute of MateriaMedica,China(No.SIMM 1501ZZ-03);support of "Youth Innovation Promotion Association"(No.2016258) from Chinese Academy of Sciences;"Young Talent Supporting Project" from China Association for Science and Technology(No.2016QNRC001);Shanghai "Pujiang Program"(No.16PJ1410600)
Two new 5-alkylpyrrole-2-carboxaldehyde derivatives,mycalenitrile-15（1） and mycalenitrile-16（2）,along with five known related ones（3-7）,were isolated from the South China Sea sponge Mycale lissochela.The structu...
关键词：5-Alkylpyrrole-2-carboxaldehyde Sponge Mycale lissochela PTP1B inhibitor Marine natural product 
Chemical Constituents from Mycelia and Spores of Fungus Cordyceps cicadae被引量：11
《Chinese Herbal Medicines》2017年第2期188-192,共5页Jia-hui Wang Zhong-liang Zhang Yu-qin Wang Min Yang Chun-hua Wang Xu-wen Li Yue-wei Guo 
National Natural Science Foundation of China(No.81520108028,81273430,41306130,81302692,41676073,81603022);SCTSM Project(No.14431901100,15431901000);Institutes for Drug Discovery and Development,Chinese Academy of Sciences(No.CASIMM0120152039);SKLDR/SIMM Projects(SIMM 1501ZZ-03);“Youth Innovation Promotion Association”from Chinese Academy of Sciences(No.2016258);“Young Talent Supporting Project”from China Association for Science and Technology(No.2016QNRC001);Shanghai“Pujiang Program”(No.16PJ1410600)
Objective To isolate and identify the chemical constituents from mycelia and spores of the fungus Cordyceps cicadae,respectively.Methods The chemical constituents were isolated and purified by repeated silica gel,Seph...
关键词：beauvericin Cordyceps cicadae cyclodesipeptide cytotoxicity sterols 
Further New Highly Oxidative Cembranoids from the Hainan Soft Coral Sarcophyton trocheliophorum被引量：1
《Natural Products and Bioprospecting》2016年第2期97-102,共6页Wen-Ting Chen Lin-Fu Liang Xu-Wen Li Wei Xiao Yue-Wei Guo 
This research work was financially supported by the National Marine“863”Projects(Nos.2013AA092902 and 2012AA092105);the Natural Science Foundation of China(Nos.81520108028,81273430,41506187,41306130,41476063);NSFC Shangdong Joint Fund for Marine Science Research Centers(Grant No.U1406402);SCTSM Project(No.14431901100 and 15431901000);the SKLDR/SIMM Projects(SIMM1203ZZ-03 and 1501ZZ-03);was partially funded by the EU 7th Framework Programme-IRSES Project(No.246987).
Three new highly oxidative cembranoids,sarcophytrols D-F(1-3),were obtained from the South China Sea soft coral Sarcophyton trocheliophorum,along with two known related ones(4 and 5).Their structures were elucidated b...
关键词：Soft coral Sarcophyton trocheliophorum Cembranoids Sarcophytrol Structure elucidation 
含时密度泛函理论-电子圆二色谱(TDDFT ECD)计算法在判定天然产物绝对构型中的应用被引量：1
《国际药学研究杂志》2015年第6期686-698,共13页黄任永 梁林富 郭跃伟 
国家海洋高技术研究发展计划(863计划)资助项目(2013AA092902,2012AA092105);国家自然科学基金资助项目(81520108028,81273430,41506187,41306130,81302692,41476063);上海市科学技术委员会科研计划项目(15431901000,14431901100);NSFC-山东海洋科学中心项目(U1406402);湖南省自然科学基金资助项目(2015JJ3176);中国科学院国家新药研究重点实验室项目(SIMM1501ZZ-03);中国科学院药物创新研究院自主部署科研项目(CASIMM0120152039)
天然产物结构鉴定过程中其立体构型的判定始终是最具有挑战性的一个环节。在解决天然产物立体化学问题的众多方法中,利用化合物的电子圆二色谱(ECD)图确定其绝对构型是一个快速、有效而可靠的方法。近年来随着量子化学计算法的发展,含...
关键词：天然产物 绝对构型 含时密度泛函理论-电子圆二色谱 
Chromopeptide A, a highly cytotoxic depsipeptide from the marine sediment-derived bacterium Chromobacterium sp. HS-13-94被引量：6
《Acta Pharmaceutica Sinica B》2015年第1期62-66,共5页Zhenfang Zhou Xin Wang Hui Zhang Jingya Sun Linghui Zheng Hongchun Liu Jidong Wang Aijun Shen Meiyu Geng Yuewei Guo 
financially supported by the National Marine ‘863’ Project (Nos. 2012AA092105 and 2013AA092902);the National Natural Science Foundation of China (No. 81273430)
A bicyclic depsipeptide, chromopeptide A(1), was isolated from a deep-sea-derived bacterium Chromobacterium sp. HS-13-94. Its structure was determined by extensive spectroscopic analysis and by comparison with a relat...
关键词：Chromopeptide A BACTERIUM DEPSIPEPTIDE Absolute configuration MARINE-DERIVED Sediments Cytotoxicity Chromobacterium sp. 
Cipatrijugin G,a new trijugin-type limonoid bearing an uncommonγ-hydroxybutenolide unit from the aerial parts of Cipadessa cinerascens被引量：2
《Natural Products and Bioprospecting》2013年第6期267-270,共4页Cheng-Shi JIANG Yan LI Zhen-Zhong WANG Xiao-Yin HUANG Wei XIAO Yue-Wei GUO 
This research work was financially supported by the National Marine‘863’Projects(No.2013AA092902);the Natural Science Foundation of China(Nos.21021063,81273430,and 2107224);was partially funded by the EU 7th Framework Programme-IRSES Project(No.246987).
A new trijugin-type limonoid,cipatrijugin G(1),together with the related known cipatrijugin A(2),were isolated from the aerial parts of Cipadessa cinerascens.The structure of the new compound was determined by extensi...
关键词：Cipadessa cinerascens trijugin-type LIMONOID 
Efficient Total Synthesis of （S）-Dihydroresorcylide, a Bioactive Twelve-Membered Macrolide被引量：1
《Chinese Journal of Chemistry》2013年第3期339-343,共5页Li Zhang Wenquan Ma Lili Xu Fei Deng Yuewei Guo 
This research work was financially supported by the Natural Science Foundation of China （Nos. 21021063, 81273430）, the National Marine ＂863＂ Project （Nos. 2011AA09070102 and 2013AA092902） and the SKLDR/SIMM Projects （No. SIMM1203ZZ-03）. We also thank Professor Minghua Xu （SIMM-CAS） for helpful discussion in preparation of this manuscript.
The efficient synthesis of （S）-dihydroresorcylide （la） along with trans-resorcylide dimethyl ether （2b）, was achieved in linear 9 steps from commercially available orcinol monohydrate （6） with esterification, ...
关键词：dihydroresorcylide trans-resorcylide dimethyl ether ring-closing metathesis （RCM） carbonylation total synthesis 
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