MARINE-DERIVED

作品数：36被引量：90H指数：5
导出分析报告
相关领域：医药卫生生物学更多>>
相关作者：朱峰林永成王斌贵陈光英王军更多>>
相关机构：中国科学院佛山科学技术学院中山大学西南科技大学更多>>
相关期刊：《Journal of Coastal Life Medicine》《Journal of Chinese Pharmaceutical Sciences》《Chinese Journal of Chemical Engineering》《Open Journal of Medicinal Chemistry》更多>>
相关基金：国家自然科学基金国家高技术研究发展计划广东省自然科学基金国家重点基础研究发展计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
A novel marine-derived anti-acute kidney injury agent targeting peroxiredoxin 1 and its nanodelivery strategy based on ADME optimization
《Acta Pharmaceutica Sinica B》2024年第7期3232-3250,共19页Ping Yu Tanwei Gu Yueyang Rao Weimin Liang Xi Zhang Huanguo Jiang Jindi Lu Jianglian She Jianmin Guo Wei Yang Yonghong Liu Yingfeng Tu Lan Tang Xuefeng Zhou 
supported by the Guangdong Local Innovation Team Program(2019BT02Y262,China);National Natural Science Foundation of China(U20A20101,82274002,22175083);Key-Area Research and Development Program of Guangdong Province(2023B1111050008,China);National Key Research and Development Program of China(2022YFA1206900,2023YFA0914200);Science and Technology Innovation Project of Guangdong Medical Products Administration(S2021ZDZ042,2023ZDZ06,2024ZDZ08,China).
Insufficient therapeutic strategies for acute kidney injury(AKI)necessitate precision therapy targeting its pathogenesis.This study reveals the new mechanism of the marine-derived anti-AKI agent,piericidin glycoside S...
关键词：Acute kidney injury Piericidin glycoside Peroxiredoxin 1 Nanodrug Kim-1 targeted ADME Marine drug Druggability 
The marine-derived compound TAG alleviates Parkinson's disease by restoring RUBCN-mediated lipid metabolism homeostasis
《Acta Pharmacologica Sinica》2024年第7期1366-1380,共15页Pei Yang Yang Liu Zhi-wu Tong Qian-hui Huang Xia-hong Xie Shi-yu Mao Jian-hua Ding Ming Lu Ren-xiang Tan Gang Hu 
supported by grants from the National Natural Science Foundation of China (No.81991523,82003725);the National Key R&D Programme of China (No.2021ZD0202901).
Parkinson’s disease(PD)is the second most common neurodegenerative disease,and its prevalence is increasing.Currently,no effective therapies for PD exist.Marine-derived natural compounds are considered important reso...
关键词：Parkinson's disease compound TAG lipid metabolism RUBCN 
A Pair of New Spirocyclic Alkaloid Enantiomers with TrxR Inhibitory Activities Were Isolated from Marine-Derived Aspergillus ruber TX-M4-1被引量：1
《Journal of Ocean University of China》2023年第6期1677-1682,共6页WANG Cong WANG Yufei SUN Jian WANG Shiyi DU Weisheng ZHOU Liman KONG Fandong 
supported by the National Natural Science Foundation of China(No.82204276);the Guangxi Natural Science Foundation(No.2021GXNSFBA075036);the Specific Research Project of Guangxi for Research Bases and Talents(Nos.AD22035018,AD20297036);the 2021 University-Level Scientific Research Projects of Guangxi Minzu University(No.2021MDKJ003);the Talent Scientific Research Initiation Project of Guangxi Minzu University(No.2021KJQD09);the Xiangsi Lake Youth Innovation Team Project of Guangxi Minzu University(No.2021 RSCXSHQN01);the Guangxi Scholarship Fund of Guangxi Education Department.
One new spirocyclic alkaloid,5-isopentenyl-cryptoechinuline D(1),along with 11 known compounds(2–12),were iso-lated from a marine fungus Aspergillus ruber TX-M4-1.The structures of compounds 1–12 were elucidated by ...
关键词：Aspergillus ruber TX-M4-1 spirocyclic alkaloid TrxR inhibitory activity 
Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum
《Chinese Chemical Letters》2023年第2期463-467,共5页Yi Ding Yu Jiang Sunjie Xu Xiujuan Xin Faliang An 
funded by the National Natural Science Foundation of China (Nos. 41876189, 81703388);the National Key R&D Program of China (Nos. 2018YFC1706206, 2019YFC0312504);supported by the Open Research Fund Program of State Key Laboratory of Bioreactor Engineering and Institute of Regulatory Science。
Perpyrrospirone A(1) characterized an unprecedented 6/5/6/8/5/13/6 oxahexacyclic scaffold with a unique peroxide-bridged 8,9-dioxa-2-azaspiro[4.7]dodecane core from marine-derived Penicillium citrinum. Compounds 2 and...
关键词：Penicillium citrinum Hirsutellone PEROXIDE X-RAY CYTOTOXICITY 
Removal process and mechanism of hexavalent chromium by adsorption-coupled reduction with marine-derived Aspergillus niger mycelial pellets被引量：1
《Chinese Journal of Chemical Engineering》2022年第9期198-204,共7页Shanshan Xu Qilei Zhang Dongmei Bai Linian Cai Tao Lu Shanjing Yao 
supported by the National Natural Science Foundation of China(21878263)。
In order to remove hexavalent chromium(Cr(Ⅵ))from solutions efficiently,the mycelial pellets with a marine-derived fungus Aspergillus niger as a biosorbent were prepared.The effects of removal process parameters such...
关键词：Cr(Ⅵ)removal Aspergillus niger Mycelial pellets ADSORBENT REDUCTION 
Structure modification,antialgal,antiplasmodial,and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives被引量：4
《Marine Life Science & Technology》2022年第1期88-97,共10页Wei-Feng Xu Na-Na Wu Yan-Wei Wu Yue-Xuan Qi Mei-Yan Wei Laura M.Pineda Michelle G.Ng Carmenza Spadafora Ji-Yong Zheng Ling Lu Chang-Yun Wang Yu-Cheng Gu Chang-Lun Shao 
supported by the Program of National Natural Science Foundation of China(Nos.U1706210,41776141,42006092,41322037 and 41830535);the Fundamental Research Funds for the Central Universities(No.201841004);the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0403-2);the Research Fund of State Key Laboratory for Marine Corrosion and Protection of Luoyang Ship Material Research Institute(LSMRI)[No.KF190402],and the Taishan Scholars Program,China(No.tsqn20161010);funded by a SENACYT grant(FID17-095)and partially by the National System of Investigators(SNI)of Panama.
Marine natural products play critical roles in the chemical defense of many marine organisms and are essential,reputable sources of successful drug leads.Sixty-seven 14-membered resorcylic acid lactone derivatives 3–...
关键词：Marine natural product 14-Membered resorcylic acid lactone Zeaenol SEMISYNTHESIS Antialgal activity Antiplasmodial activity 
Advances on marine-derived natural radioprotection compounds:historic development and future perspective
《Marine Life Science & Technology》2021年第4期474-487,共14页Reinu E.Abraham Mousa Alghazwi Qi Liang Wei Zhang 
The authors are thankful to the Center for Marine Bioproducts Development(CMBD)of Flinders University for providing the facility;The authors thank the Australian Research Council(ARC LP150100225);Gather Great Ocean Group,and Shanxi Tianzhirun Jujube Co Ltd.,China,Australian Kelp Products Pty Ltd.,Australia for their collaboration with the CMBD and the financial support.
Natural extracts and compounds from marine resources have gained intensive scientific and industry attention for radio-protective activities in the past ten years.However,the marine-derived radioprotectants have been ...
关键词：Radio-protective THERAPEUTICS Natural compounds Macro/microalgae Marine organisms Mechanism 
Marine-derived fungi as a source of bioactive indole alkaloids with diversifed structures被引量：1
《Marine Life Science & Technology》2021年第1期44-61,共18页Zhi-Hui Meng Tian-Tian Sun Guo-Zheng Zhao Yu-Fei Yue Qing-Hua Chang Hua-Jie Zhu Fei Cao 
This work was supported by the National Natural Science Foundation of China(Nos.41606174,21877025);the Scientific Research Foundation of Hebei educational committee(No.BJ2020048);the China Postdoctoral Science Foundation(No.2019M661045);the Natural Science Interdisciplinary Research Program of Hebei University(No.DXK201913).
Marine-derived fungi are well known as rich sources of bioactive natural products.Growing evidences indicated that indole alkaloids,isolated from a variety of marine-derived fungi,have attracted considerable attention...
关键词：Indole alkaloid Marine-derived fungus Chemical diversity Bioactivity 
Waixenicin A,a marine-derived TRPM7 inhibitor:a promising CNS drug lead被引量：2
《Acta Pharmacologica Sinica》2020年第12期1519-1524,共6页Hong-Shuo Sun F.David Horgen Daniel Romo Kenneth G.Hull Sigrid A.Kiledal Andrea Fleig Zhong-Ping Feng 
This paper was supported by the following grants:NIH NIGMS P20(GM103466)to FDH;DR acknowledges support by Baylor University for start-up funds to initate this project and partial support by NIH NIGMS MERIT(GM052964)and MIRA(GM134910);Hamamatsu/Queen's PET Imaging,LLC to AF;Canadian Institutes of Health Research(CIHR PJT-153155)to ZPF;Natural Sciences and Engineering Research Council of Canada(NSERC)Discovery Grants(RGPIN-2016-04574)to HSS.
Ion channels are the third largest class of targets for therapeutic drugs.The pharmacology of ion channels is an important research area for identifying new treatment options for human diseases.The past decade or so h...
关键词：ion channels TRPM7 Waixenicin A hypoxic-ischemic brain injury STROKE NEUROPROTECTION drug development 
Chemical diversity and biological function of indolediketopiperazines from marine-derived fungi被引量：3
《Marine Life Science & Technology》2020年第1期31-40,共10页Jin Cao Bin-Gui Wang 
the National Natural Science Foundation of China(NSFC Grant Nos.81673351 and 31330009).
Natural products from marine-derived fungi have attracted considerable attention in the recent two decades.Indolediketopiperazines are one of the most important classes of marine natural products,mainly discovered fro...
关键词：Indolediketopiperazines Marine-derived fungi Natural products Chemical diversity Biological function 
全选清除导出
共4页<1234>
检索报告 对象比较 聚类工具 使用帮助 返回顶部