云南高校图书馆联盟文献共享服务平台- SEMISYNTHESIS

SEMISYNTHESIS: 作品数：10被引量：35H指数：2; 导出分析报告; 相关领域：理学更多>>; 相关作者：蔡宝昌服部征雄吴皓更多>>; 相关机构：富山医科药科大学南京中医药大学更多>>; 相关期刊：《Chemical Research in Chinese Universities》《Journal of Chinese Pharmaceutical Sciences》《Marine Life Science & Technology》《National Science Review》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划更多>>

Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H_(3)K79 modifications: 《Chinese Chemical Letters》2024年第10期321-324,共4页Kun Zou Yihang Xiao jinyu Yang Mingxuan Wu; support from National Natural Science Foundation of China(Nos.22077103 and 22161132006);Westlake University startup。; Histone H3K79 modifications are essential to regulate chromatin structure and gene transcription,but understanding of the molecular mechanisms is limited.Because H3K79 is at globular domain,short histone peptide canno...; 关键词：HISTONE H3K79 modifications METHYLATION SUCCINYLATION SEMISYNTHESIS Nucleosome probes

Synthesis of Clionastatins A and B through Enhancement of Chlorination and Oxidation Levels of Testosterone被引量：1: 《Chinese Journal of Chemistry》2022年第23期2747-2755,共9页Hao Cui Yang Shen Ruifeng Wang Haoxiang Wei Xin Lei Yanyu Chen Pengfei Fu Haoxiang Wang Ruihao Bi Yandong Zhang; Financial support from the National Natural Science Foundation of China(Nos.22071205 and 21772164);NFFTBS(J1310024);NCETFJ,and PCSIRT is acknowledged.The authors are also grateful for the financial support(LMDBKF-2019-03);the Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology.; A full account of semisyntheses of polychlorinated marine steroids clionastatins A and B is described.We have developed a unique two-stage chlorination-oxidation strategy that enabled concise and divergent semisynthes...; 关键词：STEROIDS SEMISYNTHESIS CHLORINATION Oxidation PHOTOCHEMISTRY

Identification and semisynthesis of(-)-anisomelic acid as oral agent against SARS-CoV-2 in mice: 《National Science Review》2022年第11期24-31,共8页Hai-Xin Yu Nan Zheng Chi-Tai Yeh Chien-Ming Lee Qi Zhang Wen-Lv Zheng Qing Chang Yuan-He Li Yu-Jun Li Gui-Zhen Wu Jun-Min Quan Lin-Qi Zhang Yew-Min Tzeng Zhen Yang; supported by the National Natural Science Foundation of China (21772004, 21871012, 21933004, 21632002,21521003 and 22077009);the Ministry of Science and Technology of China (2022YFC0868400); (-)-Anisomelic acid,isolated from Anisomeles indica(L.)Kuntze(Labiatae)leaves,is a macrocyclic cembranolide with a trans-fusedα-methylene-γ-lactone motif.Anisomelic acid effectively inhibits SARS-Co V-2 replication ...; 关键词：IDENTIFICATION enantioselective semisynthesis (-)-anisomelic acid oral agent anti-SARS-CoV-2

Structure modification,antialgal,antiplasmodial,and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives被引量：4: 《Marine Life Science & Technology》2022年第1期88-97,共10页Wei-Feng Xu Na-Na Wu Yan-Wei Wu Yue-Xuan Qi Mei-Yan Wei Laura M.Pineda Michelle G.Ng Carmenza Spadafora Ji-Yong Zheng Ling Lu Chang-Yun Wang Yu-Cheng Gu Chang-Lun Shao; supported by the Program of National Natural Science Foundation of China(Nos.U1706210,41776141,42006092,41322037 and 41830535);the Fundamental Research Funds for the Central Universities(No.201841004);the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0403-2);the Research Fund of State Key Laboratory for Marine Corrosion and Protection of Luoyang Ship Material Research Institute(LSMRI)[No.KF190402],and the Taishan Scholars Program,China(No.tsqn20161010);funded by a SENACYT grant(FID17-095)and partially by the National System of Investigators(SNI)of Panama.; Marine natural products play critical roles in the chemical defense of many marine organisms and are essential,reputable sources of successful drug leads.Sixty-seven 14-membered resorcylic acid lactone derivatives 3–...; 关键词：Marine natural product 14-Membered resorcylic acid lactone Zeaenol SEMISYNTHESIS Antialgal activity Antiplasmodial activity

Semisynthesis and Cytotoxicity Evaluation of a Series of Ocotillol Type Saponins and Aglycones from 20（S）-Ginsenoside Rg2, Rhl, Protopanaxatriol and Their 20（R）-Epimers: 《Chemical Research in Chinese Universities》2016年第1期35-40,共6页YANG Jie YU Xue CAI Xiaoxiang CHEN Yanxin ZANG Huiming LI Xuwen JIN Yongri; Supported by the National Natural Science Foundation of China（No.31201295）.; Abstract With the oxidation treatment, eighteen compounds were separated from 20（S）-ginsenoside Rg2, Rhl, pro- topanaxatriol（PPT） and their 20（R）-epimers in total and cytotoxicity of most of them was evaluated a...; 关键词：SEMISYNTHESIS Ocotillol SAPONIN Cytotoxicity

Two new b-hydroxy amino acid-coupled secoiridoids from the flower buds of Lonicera japonica:Isolation,structure elucidation,semisynthesis,and biological activities被引量：29: 《Chinese Chemical Letters》2014年第9期1215-1219,共5页Wei-Xia Song Yong-Chun Yang Jian-Gong Shi; Financial support from the National Natural Science Foundation of China (NNSFC; Nos.20772156 and 30825044);the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT,No.IRT1007);the National Science and Technology Project of China (Nos.2012ZX09301002-002 and 2011ZX0 9307002-01); Two new β-hydroxy amino acid-coupled secoiridoids, named serinosecologanin （1） and threoninose- cologanin （2）, were isolated from an aqueous extract of the flower buds of Lonicera japonica. Their uncommon structu...; 关键词：Lonicera japonicaCaprifoliaceae β-Hydroxy amino acid-coupled secoirridoidIsolationStructure elucidationSemisynthesisBiological activity

Semisynthesis of Strychnine N-oxide and Brucine N-oxide: 《Journal of Chinese Pharmaceutical Sciences》1998年第3期57-58,共2页蔡宝昌吴皓王天山宫代博继服部征雄; 用乙醇和过氧化氢，从士的宁和马钱子碱半合成了士的宁氮氧化物和马钱子碱氮氧化物。半合成的化合物根据１ＨＮＭＲ，１３ＣＮＭＲ，ＭＳ和１Ｈ１３ＣＮＭＲ得以确证。从士的宁半合成士的宁氮氧化物的得率为９３．５６％；从马钱子碱半...; 关键词：马钱子炮制士的宁氮氧化物马钱子碱氮氧化物半合成

Two New Taxane Diterpenoids from Taxus Chinensis被引量：1: 《Chinese Chemical Letters》1998年第1期45-49,共5页Liang, JY Huang, KS Gunatilaka, AAL Yang, L; Two new taxane diterpenoids, 2-deacetoxy-7,9-dideacetyltaxinine J (1) and 2-deacetoxytaxinine B (3), were isolated from the barks of Taxus chinensis. Their structures were elucidated by spectroscopic methods.; 关键词：TAXANE DITERPENOID deacetoxy-taxinine TAXOID SEMISYNTHESIS

Studies on Semisynthesis and Anibacterial Activity of 7 β-(5-Methyl-1-Aryl-1H-1,2,3-Triazoly-4-Carboxamido) Cephalosporins: 《Chinese Chemical Letters》1997年第4期295-298,共4页Zi Yi ZHANG Yu Xiang LIANG(National Laboratory of Applied Organic Chemistry, Department of Chemistry,Lanzhou University, Lanzhou 73000)Zuo Wu GUAN(Institute of Applied Pharmacy, Beijing Medical University, Beijing 100083); Nine new derivatives of 7 β - (5- methyl- 1- aryl- 1H-1, 2, 3- triazoly- 4- carboxamido) cephalosporins were synthesized by acylction of 7 β -amino group of 7-ACA, 7-ADCA and 7-ACT with 5 -methsyl- 1 -aryl- 1 H- 1,2...; 关键词：Activity MS FAB Studies on Semisynthesis and Anibacterial Activity of 7 CEPHALOSPORINS Methyl-1-Aryl-1H-1 2 3-Triazoly-4-Carboxamido

Semisynthesis　and　Biological　Evaluation　of　Taxayuntin　13－［N－Benzoyl－（2’R，3’S）－3’－phenylisoserinate］: 《Chinese Chemical Letters》1996年第10期8-8,共2页Yue, Q Fang, QC Liang, XT; A novel taxol analog with 5/7/6/4 skeleton,taxayuntin 13-[N-benzoyl-(2'R. 3'S)3'phenylisoserinate](8) was semisynthesized with an ED50 of 11.0 μg/ml in cytotoxicity assay against KB cell line.

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