Supported by the Funds from Central Government for Guiding Local Science and Technology Development(ZY20230102);Planning Project of Scientific Research and Technology Development in Guilin(20220104-4,20210202-1);Science and Technology Planing Project of Guangxi(Guike AB24010263).
The latest progress in the process optimization and stability improvement of third-generation cephalosporins in recent years was reviewed.The introduction of green chemistry,enzyme catalysis,nanotechnology,lyophilizat...
supported by a grant from the National Natural Science Foundation of China(Grant Nos.:22176164 and 21904113);the Higher Education Discipline Innovation Project,China(Project No.:D18012).
Owing to its high sensitivity,selectivity,and accuracy,liquid chromatography coupled with mass spectrometry(LC-MS)is commonly employed to screen,confirm,and quantify impurities in drugs[1].However,LC-MS has certain dr...
Introduction Antibiotic use for acute otitis media(AOM)is one of the major sources of antimicrobial resistance.However,the effective minimal antibiotic duration for AOM remains unclear.Moreover,guidelines often recomm...
financially supported by the National Natural Science Foundation of China (No. 52070069);Jiangsu Province Natural Science Foundation (No. BK20211207);China Postdoctoral Science Foundation (No. 2021M692423);Shanghai Post-doctoral Excellence Program (No. 2020419);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD),China。
The distinct influences of cephalosporins(CEPs, i.e., cefamandole nafate and cefpirome sulfate) affiliated to different generations on the volatile fatty acids(VFAs) production and antibiotic resistance genes(ARGs) fa...
Objective: To study and analyze the intervention effect of cephalosporin clinical pharmaceutical care in promoting rational drug use. Methods: 90 patients receiving cephalosporin treatment were selected to participate...
Objective: this paper aims to explore the adverse reactions caused by the combined use of cephalosporins and a variety of western drugs, record relevant data in detail, and draw a conclusion through comparative analys...
supported by Key Laboratories of Fine Chemicals and Surfactants in Sichuan Provincial Universities (2016JXY01);the Opening Project of Key Laboratory of Green Chemistry of Sichuan Institutes of Higher Education (LYJ1105);Sichuan University of Science and Engineering talent introduction fund (2017RCL19)。
The structure of penicillin sulfoxide is rearranged to cephalosporins by the Morin rearrangement. It is a unit reaction for the preparation of various types of cephalosporins. In order to make better use of the reacti...
Objective: To investigate the prevalence of isolated organisms in patients with lower respiratory tract infections and the antibiotic susceptibilities at a tertiary care center. Methods: In this observational and cros...
An approach of using molinspiration calculations and molecular docking on PBPs (penicillin-binding proteins) and certain β-lactamases is employed to predict the molecular properties, bioactivity and resistance of n...