SUCCINYLATION

作品数：25被引量：41H指数：3
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Accessory gland protein regulates pairing process and oviposition in the subterranean termite Reticulitermes chinensis after swarming
《Insect Science》2024年第6期1889-1907,共19页Yutong Liu Fei Zhang Ali Hassan Xuguo Zhou Qiuying Huang 
supported by the National Natural Science Foundation of China(31772516 and 32170500).
Swarming and pairing behaviors are significant to population dispersal of termites.Tandem running is a key process in pairing behavior of dealates to find a mate.Succinylation can lead to significant changes in protei...
关键词：accessory gland protein OVIPOSITION SUCCINYLATION tandem running TERMITE 
Facile semisynthesis of histone H3 enables nucleosome probes for investigation of histone H_(3)K79 modifications
《Chinese Chemical Letters》2024年第10期321-324,共4页Kun Zou Yihang Xiao jinyu Yang Mingxuan Wu 
support from National Natural Science Foundation of China(Nos.22077103 and 22161132006);Westlake University startup。
Histone H3K79 modifications are essential to regulate chromatin structure and gene transcription,but understanding of the molecular mechanisms is limited.Because H3K79 is at globular domain,short histone peptide canno...
关键词：HISTONE H3K79 modifications METHYLATION SUCCINYLATION SEMISYNTHESIS Nucleosome probes 
Succinylation modification:a potential therapeutic target in stroke被引量：2
《Neural Regeneration Research》2024年第4期781-787,共7页Jie Lian Wenwu Liu Qin Hu Xiaohua Zhang 
supported by the National Natural Science Foundation of China,No.82071283(to QH);the Natural Science Foundation of Shanghai,No.22ZR1437700(to QH)。
Stroke is a leading cause of mortality and disability worldwide.Ischemic cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain injury.Imp...
关键词：mitochondria metabolism NEUROPROTECTION sirtuin 5 STROKE succinylation modification 
Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions被引量：1
《Zoological Research》2024年第1期95-107,共13页Hai-Yang Wang Lan-Xiang Liu Xue-Yi Chen Yang-Dong Zhang Wen-Xia Li Wen-Wen Li Lian Wang Xiao-Long Mo Hong Wei Ping Ji Peng Xie 
supported by the Natural Science Foundation Project of China(81820108015,82201683);China Postdoctoral Science Foundation(2021M693926,2020TQ0393,2020M683634XB);Chongqing Science&Technology Commission(cstc2021jcyj-bshX0150,cstc2021jcyj-bshX0201);Special Funding for Chongqing Postdoctoral Research Projects(2021XMT001)。
The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many diseases.However,the underlying mechanisms of gut microbe regulation of host behavior and brain f...
关键词：Gut microbiota Hippocampal protein Post-translational modifications SUCCINYLATION ACETYLATION PHOSPHORYLATION 
Lysine succinylation,the metabolic bridge between cancer and immunity
《Genes & Diseases》2023年第6期2470-2478,共9页Rui Shen Hongyun Ruan Shuye Lin Bin Liu Hang Song Lu Li Teng Ma 
supported by Youth Wan Jiang Scholar of Anhui Province,China(No.DT2100001172);Beijing Xisike Clinical Oncology Research Foundation(China)(No.Y-HR2020MS-0156).
Lysine succinylation is a naturally occurring post-translational modification(PTM)that regulates the stability and function of proteins.It can be regulated by enzymes such as SIRT5 and SIRT7.Recently,the effect and si...
关键词：IMMUNITY MITOCHONDRIA SIRT5 Succinyl-CoA SUCCINYLATION 
Protein post-translational modification by lysine succinylation:Biochemistry,biological implications,and therapeutic opportunities被引量：1
《Genes & Diseases》2023年第4期1242-1262,共21页Guo Zhao Junfeng Zhen Xinyuan Liu Jinshuai Guo Duanduan Li Jianping Xie Longxiang Xie 
supported by National Natural Science Foundation of China(No.82002172);Key Scientific Research Project Plan of Henan Province(No.20A180001);Innovation program of Henan university students(No.202110475033,20217003003).
Lysine succinylation(Ksuc)is a novel protein post-translational modification(PTM)wherein a succinyl group modifies a lysine residue.Ksuc leads to significant chemical and struc-tural changes to the modified protein.Re...
关键词：Disease EUKARYOTES Lysine succinylation Physiology PROKARYOTES Protein post-translational modification 
Ischemic accumulation of succinate induces Cdc42 succinylation and inhibits neural stem cell proliferation after cerebral ischemia/reperfusion被引量：3
《Neural Regeneration Research》2023年第5期1040-1045,共6页Lin-Yan Huang Ju-Yun Ma Jin-Xiu Song Jing-Jing Xu Rui Hong Hai-Di Fan Heng Cai Wan Wang Yan-Ling Wang Zhao-Li Hu Jian-Gang Shen Su-Hua Qi 
supported by the National Natural Science Foundation of China,No. 81671164 (to SHQ);the Natural Science Foundation of Jiangsu Province of China,No. BK20211348 (to SHQ);Xuzhou Basic Research Program,No. KC21030 (to LYH)。
Ischemic accumulation of succinate causes cerebral damage by excess production of reactive oxygen species. However, it is unknown whether ischemic accumulation of succinate affects neural stem cell proliferation. In t...
关键词：CDC42 cerebral ischemia/reperfusion injury GPR91 neural stem cells neurogenesis PROLIFERATION SIRT5 SUCCINATE SUCCINYLATION 
Sodium butyrate activates HMGCS2 to promote ketone body production through SIRT5-mediated desuccinylation
《Frontiers of Medicine》2023年第2期339-351,共13页Yanhong Xu Xiaotong Ye Yang Zhou Xinyu Cao Shiqiao Peng Yue Peng Xiaoying Zhang Yili Sun Haowen Jiang Wenying Huang Hongkai Lian Jiajun Yang Jia Li Jianping Ye 
supported by the National Key Research and Development Program of China(No.2018YFA0800603);a project(No.19ZR1439000)of the Shanghai Association for Science and Technology to Jianping Ye.
Ketone bodies have beneficial metabolic activities,and the induction of plasma ketone bodies is a health promotion strategy.Dietary supplementation of sodium butyrate(SB)is an effective approach in the induction of pl...
关键词：sodium butyrate SUCCINYLATION HMGCS2 KETOGENESIS SIRT5 
LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer被引量：1
《Genomics, Proteomics & Bioinformatics》2023年第1期177-189,共13页Oh Kwang Kwon In Hyuk Bang So Young Choi Ju Mi Jeon Ann-Yae Na Yan Gao Sam Seok Cho Sung Hwan Ki Youngshik Choe Jun Nyung Lee Yun-Sok Ha Eun Ju Bae Tae Gyun Kwon Byung-Hyun Park Sangkyu Lee 
This work was supported by the National Research Foundation of Korea and funded by the Korean Government(MSIP,Grant Nos.NRF-2018R1D1A1A02043591,2019R1H1A1079839,2020M3A9B6037812,and 2020R1A2B5B03002344);It was also supported by Korea Brain Research Institute(Grant No.21-BR-02-04).
Prostate cancer(PCa)is the most commonly diagnosed genital cancer in men worldwide.Around 80%of the patients who developed advanced PCa suffered from bone metastasis,with a sharp drop in the survival rate.Despite grea...
关键词：Sirtuin 5 Lactate dehydrogenase A Lysine succinylation PCa progression 
Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer被引量：4
《Acta Pharmacologica Sinica》2023年第1期211-220,共10页Yu-fei Wang Li-na Zhao Yu Geng Hong-feng Yuan Chun-yu Hou Hui-hui Zhang Guang Yang Xiao-dong Zhang 
This work was supported by the National Natural Science Foundation of China(No.82103066).
Aspirin as a chemopreventive agent is able to restrict the tumor growth.Phosphoglycerate mutase 1(PGAM1)is a key enzyme of glycolysis,playing an important role in the development of cancer.However,the underlying mecha...
关键词：ASPIRIN HAT1 PGAM1 SUCCINYLATION GLYCOLYSIS hepatoma carcinoma 
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