国家自然科学基金(81172876)

作品数：9被引量：46H指数：5
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葡萄糖代谢异常导致SIVmac239感染北平顶猴急性期体重变化被引量：2
《中国实验动物学报》2018年第6期693-699,共7页张瀚丹 宋天章 杨柳萌 郑永唐 
国家自然科学基金(81471620,81671627,81571606,81771770,81172876);国家科技重大专项课题(2017ZX10202102-001,2017ZX10304402-002,2018ZX10301406-003,2018ZX10301101-002)资助项目。
目的探讨艾滋病急性期炎症因子、脂类代谢及葡萄糖代谢对体重的影响。方法检测SIVmac239感染北平顶猴急性期炎症因子(TNF-α、IL-6)、脂类代谢(胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)及葡萄糖代谢参数(胰岛素、胰...
关键词：艾滋病 SIVMAC239 北平顶猴 体重 胰岛素抵抗 
Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition
《Science China(Life Sciences)》2018年第8期954-965,共12页Dan Mu Jia-Wu Zhu Feng-Liang Liu Hong-Yi Zheng Yong-Tang Zheng 
supported by grants from the National Natural Science Foundation of China (81471620, 81671627, 81571606, 81172876, U0832601);the 13th Five-Year Key Scientific and Technological Program of China (2017ZX10304402-002-004, 2017ZX10202102-001-005);the Knowledge Innovation Program of the Chinese Academy of Sciences (KJZD-EW-L1002, KSCX2-EW-R-13);the National Key Research & Development Plan (2016YFC1201000);the National Basic Research Program of China (2012CBA01305)
TRIM5α restricts retroviruses in a species-specific manner. Cyclophilin A was independently retrotransposed into the TRIM5 loci in different species, leading to the generation of antiviral TR1M5-cyclophilin A （TRIM...
关键词：TRIMCyp/TRIM5α assam macaque HIV-1 N-MLV functional trade-off 
抗登革病毒化学药物研究进展被引量：5
《中国药学杂志》2017年第10期809-813,共5页张高红 郑永唐 
国家自然科学基金资助项目(81273251,81172876)
登革热是由埃及伊蚊和白纹伊蚊传播的一种重要虫媒病毒引起的疾病。登革病毒感染能够引起登革热、登革出血热和登革休克综合征等多种症状。迄今为止尚无抗登革病毒药物上市。研发中的药物按照作用机制可分为抗登革病毒的复制周期抑制剂...
关键词：登革热 登革热病毒 登革出血热 登革休克综合征 抗登革病毒药物 
平顶猴主要组织相容性复合物基因研究进展
《国际免疫学杂志》2016年第1期47-52,共6页连晓东 郑永唐 
基金项目：国家自然科学基金（81172876）
平顶猴是目前唯一被报道可被人类免疫缺陷病毒1型（HIV-1）感染的旧大陆猴,并且已成为在研究HIV致病机制、抗病毒药物和疫苗研发中极具前景的动物模型.随着平顶猴在动物模型中日益广泛的应用,其免疫系统相关的基础数据,尤其是主要组织...
关键词：平顶猴 动物模型 MHC 人类免疫缺陷病毒1型 
艾滋病猕猴模型的肠道病理学研究进展被引量：8
《免疫学杂志》2015年第3期265-269,276,共6页张琳萄 夏雪山 郑永唐 
国家自然科学基金(81172876,81273251,81471620,U1202228);国家重大科学研究计划课题(2012CBA01305);国家科技重大专项课题(2012ZX10001-007,2013ZX10001-002)
HIV是导致AIDS的病原体,HIV感染后会引起机体免疫缺陷并导致多个器官的损伤,其中肠道损伤是HIV感染后最常见的病变之一。肠道损伤既是HIV致病的直接诱因,也能间接地影响机体多项免疫功能进而加速疾病进展。非人灵长类动物在组织结构、...
关键词：AIDS SIV 灵长类动物 胃肠道 病理学变化 
Experimental primates and non-human primate(NHP) models of human diseases in China: current status and progress被引量：19
《Zoological Research》2014年第6期447-464,共18页Xiao-Liang ZHANG Wei PANG Xin-Tian HU Jia-Li LI Yong-Gang YAO Yong-Tang ZHENG 
supported by the National Natural Science Foundation of China(81172876,81273251,U1202228,81471620);the National Special Science Research Program of China(2012CBA01305);the National Science and Technology Major Project(2013ZX10001-002,2012ZX10001-007);the Knowledge Innovation Program of CAS(KSCX2-EW-R-13,KJZD-EW-L10-02)
Non-human primates （NHPs） are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biom...
关键词：Non-human primates Experimental primates Animal models Current status 
Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques （Macaca leonina）被引量：4
《Zoological Research》2014年第6期465-473,共9页Hong-Yi ZHENG Ming-Xu ZHANG Lin-Tao ZHANG Xiao-Liang ZHANG Wei PANG Long-Bao LYU Yong-Tang ZHENG 
This work was supported by the National Special Science Research Program of China （2012CBA01305）; the National Natural Science Foundation of China （81172876, U0832601, 81273251, U1202228）; the Knowledge Innovation Program of CAS （KSCX2-EW-R-13） and the National Science and Technology Major Project （2013ZX10001-002, 2012ZX10001-007）We thank Mr. Zhen-Fei Hu,Gui Li and Dong-Ti Huang of Kunming Primate Research Center for their assistance with the experiments.
Pig-tailed macaques(Macaca nemistrina group) have been extensively used as non-human primate animal models for various human diseases in recent years, notably for AIDS research due to their sensitivity to HIV-1. North...
关键词：Northern pig-tailed macaque Flow cytometry Leukocyte subpopulation Age Sex 
Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque （Macaca leonina）被引量：5
《Zoological Research》2014年第3期186-195,共10页Ai-Hua LEI Gao-Hong ZHANG Ren-Rong TIAN Jia-Wu ZHU Hong-Yi ZHENG Wei PANG Yong-Tang ZHENG 
Foundation items： This work was supported by the National Basic Research Program （2012CBA01305）; the National Natural Science Foundation of China （81172876, U0832601, 81273251 and U 1202228） the Knowledge Innovation Program of CAS （KSCX2-EW-R-13, Y206A- 71181）, and the Key Scientific and Technological Program of China （2012ZX10001-007, 2013ZX10001-002）. Acknowledgements： We thank Prof. Guang-Xia GAO （Institute of Biophysics, Chinese Academy of Sciences） for kindly providing HSIV proviral plasmids.We also thank Long-Bao LV, Gui LI and Dong- Ti HUANG of Kunming Primate Research Center for their assistance in obtaining blood samples from northem pig-tailed macaques （M. leonina） and Chinese rhesus macaques.
The northern pig-tailed macaque （Macaca leonina） has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus...
关键词：HIV-1 HSIV REPLICATION PBMC Northern pig-tailed macaque （Macaca leonina） 
Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques （Macaca leonina）被引量：8
《Zoological Research》2014年第3期196-203,共8页Xiao-Liang ZHANG Wei PANG De-Yao DENG Long-Bao LV Yue FENG Yong-Tang ZHENG 
Foundation items： This work was supported by the National Natural Science Foundation of China （81172876, U0832601, 81273251, U1202228）; the National Special Science Research Program of China （2012CBA01305）; the National Science and Technology Major Project （2013ZX10001-002, 2012ZX10001-007） and the Knowledge Innovation Program of CAS （KSCX2-EW-R-13）.
The northem pig-tailed macaque （NPM, Macaca leonina） has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3...
关键词：Northern pig-tailed macaque （Macaca leonina） IMMUNOGLOBULIN Complement C-reactive protein 
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