国家自然科学基金(81273454)

作品数：8被引量：8H指数：2
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相关作者：齐宪荣仰浈臻孟婷婷李井泉刘瑜洁更多>>
相关机构：北京大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《药学研究》更多>>
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Characterization of amphiphilic dendrimer modified PEG-PLA nanoparticles prepared by a double emulsion-solvent evaporation method
《Journal of Chinese Pharmaceutical Sciences》2017年第7期521-527,共7页李欣 庞宁 李骥 齐宪荣 
National Natural Science Foundation of China(Grant No.81473156,81673365,81273454);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055);National Key Basic Research Program(Grant No.2013CB932501)
Drug delivery by nanocarriers requires characterizations of suitable particle size, high drug loading and safety. In this work, we prepared an amphiphilic dendrimer modified PEG-PLA mixed nanoparticles（NPs） by a dou...
关键词：PEG-PLA nanoparticles DOCETAXEL PACLITAXEL Double emulsion-solvent evaporation method Amphiphilic dendrimer 
Preparation and characterization of mesoporous silica nanoparticles with enlarged pores capped with crosslinked PEI
《Journal of Chinese Pharmaceutical Sciences》2015年第11期712-720,共9页孙璐 刘瑜洁 仰浈臻 齐宪荣 
National Natural Science Foundation of China(Grant No.81273454 and 81473156);Beijing Nature Science Fo undation(Grant No.7132113);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055);National Key Ba sic Research Program(Grant No.2013CB932501)
The epidemiological statistics reveals the striking patterns of cancer in women and highlights the need for novel therapeutic strategies. In this work, mesoporous silica nanoparticles（MSNs） as representative of inor...
关键词：Mesoporous silica nanoparticle PREPARATION POLYETHYLENIMINE MCF-7 cells 
Folate and cell penetrating peptide modification effects on penetration behavior of nanostructured lipid carriers using multicellular tumor spheroids被引量：1
《Journal of Chinese Pharmaceutical Sciences》2015年第10期666-672,共7页庄鸿蒙 孟婷婷 高玮 袁兰 齐宪荣 
National key Basic Research Program(Grant No.2013CB932501);National Natural Science Foundation of China(Grant No.81273454 and 81473156);Beijing National Science Foundation(Grant No.7132113);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055)
Surface modification may have important influences on the penetration behavior of nanoscale drug delivery system. In the present study, we mainly focused on whether cell targeting or cell penetration could affect pene...
关键词：Nanostructured lipid carriers Multicellular tumor spheroids Stacking method Folate Cell penetrating peptide 
Preparation and anti-MDR tumors study of folate and TPGS dual-modified DSPE-PEG micelles loaded with docetaxel被引量：1
《Journal of Chinese Pharmaceutical Sciences》2015年第7期419-426,共8页王爱婷 佟淑文 胡新 齐宪荣 
National Natural Science Foundation of China(Grant No.81273454 and 81473156);Beijing National Science Foundation(Grant No.7132113);National Key Basic Research Program(Grant No.2013CB932501);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055)
Multidrug resistance （MDR） operated by P-glycoprotein （P-gp） is one of the major causes in the treatment failure of cancers. In this work, docetaxel-loaded mixed micelles comprised of 1,2-distearoyl-sn-glycero-3-p...
关键词：Micelles Multidrug resistance PREPARATION DSPE-PEG TPGS Folate 
The use of cationic liposomes to co-deliver docetaxel and siRNA for targeted therapy of hepatocellular carcinoma被引量：3
《Journal of Chinese Pharmaceutical Sciences》2014年第10期667-673,共7页李井泉 仰浈臻 孟婷婷 齐宪荣 
National Natural Science Foundation of China(Grant No.81273454);Beijing National Science Foundation(Grant No.7132113);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055);Innovation Team of Ministry of Education(Grant No.BMU20110263)
Hepatocellular carcinoma （HCC） is one of the major causes of death worldwide. Targeted delivery of drugs to tumor cells can be achieved by introduction of a targeting ligand onto the nanocarrier system. Simultaneous...
关键词：SP94 Hepatocellular carcinoma Liposomes DOCETAXEL SIRNA 
脑胶质瘤治疗及其动物模型的研究进展被引量：2
《药学研究》2014年第10期559-563,共5页仰浈臻 刘瑜洁 齐宪荣 
国家基础研究计划(No.2013CB932501);国家自然科学基金(No.81273454);北京市自然科学基金(No.7132113);教育部博士点基金(20130001110055)资助项目
脑胶质瘤是原发性中枢神经细胞肿瘤中最常见并且死亡率最高的肿瘤。尽管对其研究的重视程度日渐增加,胶质瘤依然是现今最难治疗的肿瘤。许多候选药物在临床前试验有较好效果的药物在临床试验后期失败,提示动物模型的改进的必要性。随着...
关键词：脑胶质瘤 治疗策略 动物模型 
Preparation and evaluation of lipid-matrix nanocarrier co-delivery gene and sensibilizer to elevate docetaxel antitumor被引量：1
《Journal of Chinese Pharmaceutical Sciences》2014年第3期145-152,共8页孟婷婷 李井泉 齐宪荣 
National Natural Science Foundation of China(Gr ant No.81273454);Beijing Natural Science Foundation(Grant No.7132113);Doctoral Foundation of the Ministry of Education(Grant No.20100001110056 and 20130001110055)
It is a promising treatment strategy to use a nanoparticle-based drug delivery system for cancer patients, which can simultaneously deliver multiple drugs or genes in combination with therapy to induce synergistic eff...
关键词：Co-delivery system DOCETAXEL Small-interfering RNAs CURCUMIN PREPARATION 
Hematological and pathological toxicity of anti-HER2/neu peptide mimetic modified paclitaxel bovine serum albumin nanoparticles
《Journal of Chinese Pharmaceutical Sciences》2013年第5期441-448,共8页王占璋 仰浈臻 齐宪荣 
the National Natural Science Foundation of China(Grant No.30970785,81273454);Beijing Natural Science Foundation(Grant No.7132113);National Basic Research Program(Grant No.2009CB930303,2013CB932501);Doctoral Foundation of the Ministry of Education(Grant No.20100001110056);Innovation Team of Ministry of Education(Grant No.BMU20110263)
Nanoparticles have been widely applied in diagnosis and therapy due to the high loading of insoluble drug, increased target accumulation and interaction with biological tissues. Recently, severe side effects of nanopa...
关键词：Albumin nanoparticle Anti-HER2/neu peptide mimetic Target delivery Toxicity PACLITAXEL 
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