国家自然科学基金(81172992)

作品数：5被引量：6H指数：2
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相关机构：北京大学更多>>
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The cellular uptake and anti-tumor activity of conjugated linoleic acid-paclitaxelloaded iRGD-modified lysolipid-containing thermosensitive liposomes被引量：4
《Journal of Chinese Pharmaceutical Sciences》2019年第2期121-133,共13页Yanli Hao Ting Zhong Ruo Du Hua Zhang Bilin Liu Xuan Zhang 
National Natural Science Foundation of China(Grant No.81172992);the National Key Research and Development Program of China(Grant No.2017YFA0205600)
In the present study, we prepared the iRGD-modified lysolipid-containing thermosensitive liposomes(LTSL) containing conjugated linoleic acid-paclitaxel(CLA-PTX), also known as iRGD-LTSL-CLA-PTX. The in vitro cellular ...
关键词：iRGD Lysolipid-containing thermosensitive liposomes CLA-PTX Antitumor effect In vitro In vivo 
The targeting effect of H_7K(R_2)_2-modified pH-sensitive liposomes on U87-MG cells
《Journal of Chinese Pharmaceutical Sciences》2015年第10期660-665,共6页赵阳 任伟 钟婷 王超 张卫强 黄丹 张爽 郭阳 姚鑫 张烜 张强 
Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20120001110012);the National Basic Research Program of China(973 Program,Grant No.2013CB932501);National Natural Science Foundation of China(Grant No.81172992)
The present study aimed to investigate the targeting effect of H7K（R2）2-modified pH -sensitive liposomes on U87-MG cells. Using coumarin-6 as a fluorescence probe, we prepared H7K（R2）2-modified p H-sensitive lipos...
关键词：H7K（R2）2-modified pH-sensitive liposomes Cellular uptake pathway Secondary structure U87-MG cells 
The anti-tumor efficacy of c9,t11-CLA-PTX and t10,c12-CLA-PTX on MCF-7 breast cancer cells:in vitro and in vivo
《Journal of Chinese Pharmaceutical Sciences》2014年第11期751-759,共9页杨科 李星火 李丹 柯曦宇 张烜 张强 
National Natural Science Foundation of China (Grant No.81172992);the National Basic Research Program of China (973 Program,Grant No.2013CB932501);Innovation Team of Ministry of Education (Grant No.BMU20110263)
Considering the results of our previous research that conjugated linoleic acid mixture-paclitaxel （CLA-mixture-PTX） possesses anti-tumor activity against melanoma and brain glioma, the purpose of this study was to i...
关键词：C9 tl 1-CLA-PTX T10 c12-CLA-PTX Apoptosis Cell cycle Cellular uptake Anti-tumor efficacy 
The preparation and characteristics of febuxostat SiO2 solid dispersions被引量：2
《Journal of Chinese Pharmaceutical Sciences》2014年第7期463-470,共8页宋文丁 杜若 宋平 钟婷 张卫强 赵阳 王超 张烜 张强 
National Natural Science Foundation of China(Grant No.81172992);the National Basic Research Program of China(Grant No.973 Program 2009CB930300);Innovation Team of Ministry of Education(Grant No.BMU20110263)
In the present research, we selected Sylysia as a porous material and febuxostat（FBT） as model drug to prepare the FBT SiO2 solid dispersions using a solvent evaporation method. We firstly established an HPLC method...
关键词：FEBUXOSTAT Sylysia Solid dispersion Solubility and dissolution 
In vitro and in vivo antitumor efficacy of CLA-PTX on B16-F10 melanoma cells
《Journal of Chinese Pharmaceutical Sciences》2014年第1期46-53,共8页李捷思 杨科 柯曦宇 杜若 张烜 张强 
National Natural Science Foundation of China(Grant No.81172992);the National Basic Research Program of China(973 Program,Grant No.2009CB930300);Innovation Team of Ministry of Education(Grant No.BMU20110263)
The purpose of this study was to investigate the potential antitumor efficacy of conjugated linoleic acid-paclitaxel （CLA-PTX） on B16-F10 melanoma cell line in vitro and in vivo. The in vitro cytotoxicity, apoptosis...
关键词：CLA-PTX APOPTOSIS Cell cycle Cellular uptake Antitumor efficacy 
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