This study was supported by the National Natural Science Foundation of China (No 81072702 and No 81071116) and the major research and development project on innovative drugs, China Ministry of Science and Technology (2012ZX09303004- 001) The authors thank PhD candidates Mr Stephen Charles CROUCH and Miss Yu-zheng WANG (Albany College of Pharmacy and Health Sciences, NY, USA) for their critical reading and reviewing of the manuscript. The authors are also grateful to the anonymous reviewer for his valuable com- ments.
Aim: To study the effects of delayed and missed doses (poor compliance) on the pharmacokinetics of carbamazepine (CBZ) and its main active metabolite carbamazepine-10,11-epoxide (CBZE) in Chinese epilepsy patie...