supported by the National Natural Science Foundation of China(No.81102035,and 82060388);Doctor Foundation of Guizhou Provincial People's Hospital(No.GZSYBS[2019]08);Guizhou High-level Innovative Talents Project(No.QKPT[2017]5724-6);Guizhou Department and Platform Talents(No.[2017]5735-31);Science and Technology Department of Guizhou Province(No.QKHJC[2021-396]).
Osteosarcoma (OS) is the most common histological form of primary bone cancer in childhood cancer and young adults. At present, OS is widely investigated because of the interaction between the tumor and bone microenvi...