国家自然科学基金(81301905)

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相关期刊:《Acta Pharmacologica Sinica》更多>>
相关主题:HSP27GLIOMADAPTP38_MAPKΓ-SECRETASE更多>>
相关领域:生物学农业科学更多>>
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γ-Secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro via blocking the p38 MAPK/MAPKAPK2/Hsp27 pathway
《Acta Pharmacologica Sinica》2014年第6期825-831,共7页Jun-yang LI Ru-jun LI Han-dong WANG 
Acknowledgements We thank Prof Bruce D HAMMOCK for providing the sEH inhibitor t-AUCB. This study was supported by the National Natural Science Foundation of China (No 81070974 and No 81301905).
Aim: Trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) is a soluble epoxide hydrolase inhibitor that suppresses glioblastoma cell growth in vitro. The aim of this study was to examine whet...
关键词:GLIOMA chemotherapy Γ-SECRETASE DAPT soluble epoxide hydrolase t-AUCB apoptosis caspase-3 p38 MAPK MAPKAPK2 HSP27 
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