Acknowledgements This study was supported by the National Natural Science Foundation of China (No 30670994 and 30940038) and the Natural Science Foundation of Shandong Province (No Q2006C15).
Aim: To investigate whether AMP-activated protein kinase (AMPK) regulates the expression of pancreatic duodenal homeobox-1 (PDX- 1), a β-cell-specific transcription factor and whether PPARa/γ is involved in the...
Project supported by a grant from National Natural Science Foundation of China (№ 30670994).Acknowledgements The authors thank Professor Xiao HAN for providing us with the INS-1 cells, and also the teachers at the Science Center of Shandong Provincial Hospital (Jinan, China) for excellent technical assistance.
Aim: Adenosine monophosphate-activated protein kinase (AMPK), a vital regulator of glucose metabolism, may affect insulin secretion in β-cells. However, the role of AMPK in β-cell lipotoxicity remains unclear. Fe...